U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Egr1 early growth response 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24330, updated on 9-Dec-2024

    Summary

    Official Symbol
    Egr1provided by RGD
    Official Full Name
    early growth response 1provided by RGD
    Primary source
    RGD:2544
    See related
    EnsemblRapid:ENSRNOG00000019422 AllianceGenome:RGD:2544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ngf1; Ngfi; NGFI-A; Krox-24; zif-268
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of synaptic plasticity; and response to isoquinoline alkaloid. Located in cytoplasm and nucleus. Biomarker of several diseases, including cocaine dependence; lung disease (multiple); middle cerebral artery infarction; pulmonary hypertension; and visual epilepsy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 21.7), Brain (RPKM 17.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Egr1 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26737078..26740877)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26462967..26466766)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27657903..27660101)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 3B Neighboring gene receptor accessory protein 2 Neighboring gene 5S ribosomal RNA Neighboring gene small nucleolar RNA SNORA26 Neighboring gene eukaryotic translation termination factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables double-stranded DNA binding PubMed 
    enables double-stranded methylated DNA binding  
    enables double-stranded methylated DNA binding  
    enables enzyme binding  
    enables hemi-methylated DNA-binding  
    enables hemi-methylated DNA-binding  
    enables histone acetyltransferase binding  
    enables histone acetyltransferase binding  
    enables promoter-specific chromatin binding PubMed 
    enables promoter-specific chromatin binding  
    enables promoter-specific chromatin binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 32
    Items 1 - 25 of 111
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    acts_upstream_of_or_within BMP signaling pathway  
    involved_in T cell differentiation  
    acts_upstream_of_or_within T cell differentiation  
    involved_in cellular response to antibiotic PubMed 
    involved_in cellular response to cAMP PubMed 
    involved_in cellular response to follicle-stimulating hormone stimulus PubMed 
    involved_in cellular response to gamma radiation  
    involved_in cellular response to gamma radiation  
    involved_in cellular response to gonadotropin stimulus PubMed 
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in cellular response to heparin PubMed 
    involved_in cellular response to hyperoxia PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    involved_in cellular response to interleukin-8  
    involved_in cellular response to interleukin-8  
    involved_in cellular response to interleukin-8  
    involved_in cellular response to isoquinoline alkaloid PubMed 
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to mycophenolic acid PubMed 
    involved_in cellular response to steroid hormone stimulus PubMed 
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian rhythm PubMed 
    involved_in circadian temperature homeostasis  
    involved_in circadian temperature homeostasis  
    involved_in circadian temperature homeostasis  
    involved_in estrous cycle  
    involved_in estrous cycle  
    involved_in estrous cycle  
    involved_in glomerular mesangial cell proliferation PubMed 
    involved_in interleukin-1-mediated signaling pathway  
    involved_in interleukin-1-mediated signaling pathway  
    involved_in learning or memory PubMed 
    involved_in learning or memory PubMed 
    involved_in locomotor rhythm  
    involved_in locomotor rhythm  
    involved_in locomotor rhythm  
    involved_in long-term memory PubMed 
    involved_in long-term synaptic potentiation PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in oligodendrocyte differentiation PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression via chromosomal CpG island demethylation  
    involved_in positive regulation of gene expression via chromosomal CpG island demethylation  
    involved_in positive regulation of glomerular metanephric mesangial cell proliferation PubMed 
    involved_in positive regulation of hormone biosynthetic process  
    involved_in positive regulation of hormone biosynthetic process  
    involved_in positive regulation of hormone biosynthetic process  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of post-translational protein modification  
    involved_in positive regulation of post-translational protein modification  
    involved_in positive regulation of smooth muscle cell migration PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of apoptotic process  
    involved_in regulation of long-term neuronal synaptic plasticity PubMed 
    involved_in regulation of neuron apoptotic process PubMed 
    involved_in regulation of progesterone biosynthetic process  
    involved_in regulation of progesterone biosynthetic process  
    involved_in regulation of progesterone biosynthetic process  
    involved_in regulation of protein sumoylation  
    involved_in regulation of protein sumoylation  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in response to amphetamine PubMed 
    involved_in response to carbon monoxide PubMed 
    involved_in response to cocaine PubMed 
    involved_in response to electrical stimulus PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to follicle-stimulating hormone PubMed 
    involved_in response to glucose  
    involved_in response to glucose  
    involved_in response to gonadotropin PubMed 
    involved_in response to hypoxia  
    involved_in response to hypoxia  
    involved_in response to hypoxia  
    involved_in response to insulin  
    involved_in response to insulin  
    involved_in response to ischemia PubMed 
    involved_in response to ischemia  
    involved_in response to ischemia  
    involved_in response to morphine PubMed 
    involved_in response to norepinephrine PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in skeletal muscle cell differentiation  
    acts_upstream_of_or_within skeletal muscle cell differentiation  
    Items 1 - 25 of 111
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    early growth response protein 1
    Names
    nerve growth factor-induced protein A
    transcription factor Zif268
    zinc finger protein Krox-24

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012551.3NP_036683.2  early growth response protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      P08154, Q53YM5
      UniProtKB/TrEMBL
      A0A0H2UHR3, A6J2W7
      Related
      ENSRNOP00000026303.4, ENSRNOT00000026303.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      26737078..26740877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.