Pzp pregnancy-zone protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pzpprovided by RGD
Official Full Name: pregnancy-zone proteinprovided by RGD
Primary source: RGD:628643
See related: EnsemblRapid:ENSRNOG00000006709 AllianceGenome:RGD:628643
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: A1m
Summary: Enables brain-derived neurotrophic factor binding activity and nerve growth factor binding activity. Predicted to be involved in embryo implantation and negative regulation of peptidase activity. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 11089.4) See more
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Genomic context

Location:: 4q42

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (163445265..163491358, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (161759176..161805271, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (161804792..161850877, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alpha1-M is proved to be a potential serum factor related to obesity proneness and obesity resistance.
Title: Alpha1-macroglobulin: a potential obesity-related factor in serum.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables brain-derived neurotrophic factor binding	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nerve growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-1-macroglobulin

Names: alpha-1-M; alpha-1-macroglobulin 165 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145779.2 → NP_665722.2 alpha-1-macroglobulin precursor

See identical proteins and their annotated locations for NP_665722.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q63041, Q63332

UniProtKB/TrEMBL

A0A8L2Q3W7, A6IM16

Related

ENSRNOP00000009467.5, ENSRNOT00000009467.8

Conserved Domains (7) summary

COG2373
Location:127 → 1127

YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]

cd02897
Location:972 → 1287

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:752 → 842

A2M; Alpha-2-macroglobulin family

pfam01835
Location:127 → 219

A2M_N; MG2 domain

pfam07677
Location:1400 → 1487

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1024 → 1289

A2M_comp; A-macroglobulin complement component

pfam07703
Location:460 → 605

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

163445265..163491358 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008763310.3 → XP_008761532.1 alpha-1-macroglobulin isoform X1

UniProtKB/TrEMBL

A0A8L2Q3W7

Conserved Domains (6) summary

cd02897
Location:961 → 1276

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:741 → 831

A2M; Alpha-2-macroglobulin family

pfam01835
Location:127 → 219

A2M_N; MG2 domain

pfam07677
Location:1389 → 1476

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1013 → 1278

A2M_comp; A-macroglobulin complement component

pfam07703
Location:460 → 605

A2M_N_2; Alpha-2-macroglobulin family N-terminal region