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    Ddx52 DExD-box helicase 52 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85432, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ddx52provided by RGD
    Official Full Name
    DExD-box helicase 52provided by RGD
    Primary source
    RGD:621743
    See related
    EnsemblRapid:ENSRNOG00000053814 AllianceGenome:RGD:621743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rok1
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in nucleolus. Orthologous to human DDX52 (DExD-box helicase 52). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 134.7), Spleen (RPKM 108.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddx52 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (69322062..69344856)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68824594..68847400)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71253667..71276397)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 6 Neighboring gene uncharacterized LOC134480708 Neighboring gene HNF1 homeobox B Neighboring gene uncharacterized LOC134480841 Neighboring gene synergin, gamma Neighboring gene uncharacterized LOC134480839

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Group II phospholipase A2 inhibitors suppressed lysophosphatidylserine-dependent degranulation of rat peritoneal mast cells. Murakami M, et al. Biochem Biophys Res Commun, 1991 Dec 16. PMID 1721808
    2. Rok1p is a putative RNA helicase required for rRNA processing. Venema J, et al. Mol Cell Biol, 1997 Jun. PMID 9154839, Free PMC Article
    3. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Saad Y, et al. Genomics, 2007 Mar. PMID 17218081, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX52
    Names
    ATP-dependent, RNA helicase
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
    DEAD box protein 52
    DEAD-box helicase 52
    rROK1L
    NP_445977.1
    XP_038942927.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053525.1 → NP_445977.1  probable ATP-dependent RNA helicase DDX52

      See identical proteins and their annotated locations for NP_445977.1

      Status: PROVISIONAL

      Source sequence(s)
      AB055628
      UniProtKB/Swiss-Prot
      Q99PT0
      UniProtKB/TrEMBL
      A1EC69, A6HHJ6, Q5FWY7
      Related
      ENSRNOP00000003600.3, ENSRNOT00000003600.8
      Conserved Domains (3) summary
      PRK11192
      Location:163 → 591
      PRK11192; ATP-dependent RNA helicase SrmB; Provisional
      pfam00271
      Location:399 → 508
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:170 → 376
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      69322062..69344856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086999.2 → XP_038942927.1  probable ATP-dependent RNA helicase DDX52 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GB03, A1EC69, Q5FWY7
      Related
      ENSRNOP00000083648.1, ENSRNOT00000119012.2
      Conserved Domains (2) summary
      COG0513
      Location:137 → 574
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd17957
      Location:177 → 378
      DEADc_DDX52; DEAD-box helicase domain of DEAD box protein 52
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PT0.1 GenPept UniProtKB/Swiss-Prot:Q99PT0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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