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    Lst1 leukocyte specific transcript 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64569, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lst1provided by RGD
    Official Full Name
    leukocyte specific transcript 1provided by RGD
    Primary source
    RGD:620077
    See related
    EnsemblRapid:ENSRNOG00000000855 AllianceGenome:RGD:620077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    B144
    Summary
    Predicted to be involved in dendrite development and negative regulation of lymphocyte proliferation. Predicted to be located in cytosol and plasma membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in graft-versus-host disease. Orthologous to human LST1 (leukocyte specific transcript 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 59.0), Lung (RPKM 33.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Lst1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3639353..3644399)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3634680..3639731)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5175213..5179352, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor Neighboring gene lymphotoxin beta Neighboring gene natural cytotoxicity triggering receptor 3 Neighboring gene allograft inflammatory factor 1 Neighboring gene E230034O05Rik gene Neighboring gene proline-rich coiled-coil 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in cell morphogenesis  
    involved_in dendrite development  
    involved_in dendrite development  
    involved_in immune response  
    involved_in negative regulation of lymphocyte proliferation  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    is_active_in membrane  
    located_in membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    leukocyte-specific transcript 1 protein
    Names
    leucocyte specific transcript 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022634.2 → NP_072156.2  leukocyte-specific transcript 1 protein

      See identical proteins and their annotated locations for NP_072156.2

      Status: VALIDATED

      Source sequence(s)
      BX883046
      UniProtKB/TrEMBL
      A0A9K3Y6U3, E9PST7, Q6MG46, Q9QXI4
      Related
      ENSRNOP00000098089.2, ENSRNOT00000120407.2
      Conserved Domains (1) summary
      pfam05083
      Location:54 → 118
      LST1; LST-1 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3639353..3644399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279496.1 → XP_063135566.1  leukocyte-specific transcript 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4K1
    2. XM_006256080.4 → XP_006256142.1  leukocyte-specific transcript 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4K1
      Related
      ENSRNOP00000098088.2, ENSRNOT00000120406.2
      Conserved Domains (1) summary
      pfam05083
      Location:36 → 100
      LST1; LST-1 protein
    3. XM_006256078.5 → XP_006256140.1  leukocyte-specific transcript 1 protein isoform X1

      See identical proteins and their annotated locations for XP_006256140.1

      UniProtKB/TrEMBL
      A0A9K3Y6U3, E9PST7, Q6MG46, Q9QXI4
      Conserved Domains (1) summary
      pfam05083
      Location:54 → 118
      LST1; LST-1 protein
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