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    Tnnt1 troponin T1, slow skeletal type [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171409, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnnt1provided by RGD
    Official Full Name
    troponin T1, slow skeletal typeprovided by RGD
    Primary source
    RGD:621852
    See related
    EnsemblRapid:ENSRNOG00000028041 AllianceGenome:RGD:621852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    sTnT; tnTs; Fang2
    Summary
    Enables troponin T binding activity. Involved in slow-twitch skeletal muscle fiber contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in nemaline myopathy 5A; nemaline myopathy 5B; and nemaline myopathy 5C. Orthologous to human TNNT1 (troponin T1, slow skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 4333.7) See more
    Orthologs
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    Genomic context

    See Tnnt1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78349035..78359394)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69306362..69316721)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72889270..72899629)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, assembly factor 3 Neighboring gene troponin I3, cardiac type Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene EPS8-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tropomyosin binding  
    enables tropomyosin binding  
    enables troponin T binding  
    enables troponin T binding PubMed 
    Component Evidence Code Pubs
    part_of troponin complex  
    part_of troponin complex PubMed 
    part_of troponin complex  
    part_of troponin complex  

    General protein information

    Preferred Names
    troponin T, slow skeletal muscle
    Names
    slow skeletal muscle troponin T
    troponin T type 1 (skeletal, slow)
    troponin T1, skeletal, slow

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277260.1NP_001264189.1  troponin T, slow skeletal muscle isoform 2

      See identical proteins and their annotated locations for NP_001264189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AY334080, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNL6
      Conserved Domains (1) summary
      pfam00992
      Location:67203
      Troponin; Troponin
    2. NM_001277261.2NP_001264190.1  troponin T, slow skeletal muscle isoform 3

      See identical proteins and their annotated locations for NP_001264190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AY334082, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNL6
      Conserved Domains (1) summary
      pfam00992
      Location:56192
      Troponin; Troponin
    3. NM_001277262.2NP_001264191.1  troponin T, slow skeletal muscle isoform 4

      See identical proteins and their annotated locations for NP_001264191.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AY334081, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNL6
      Related
      ENSRNOP00000055633.4, ENSRNOT00000058843.7
      Conserved Domains (1) summary
      pfam00992
      Location:57193
      Troponin
    4. NM_134388.2NP_599215.2  troponin T, slow skeletal muscle isoform 1

      See identical proteins and their annotated locations for NP_599215.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AY334079, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q7TNA9, Q7TNB0, Q7TNB1, Q7TNB2, Q923S7
      UniProtKB/TrEMBL
      A6KNL6
      Related
      ENSRNOP00000038327.4, ENSRNOT00000034957.8
      Conserved Domains (1) summary
      pfam00992
      Location:68204
      Troponin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78349035..78359394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276629.1XP_063132699.1  troponin T, slow skeletal muscle isoform X1

    2. XM_063276722.1XP_063132792.1  troponin T, slow skeletal muscle isoform X5

    3. XM_063276740.1XP_063132810.1  troponin T, slow skeletal muscle isoform X6

    4. XM_063276683.1XP_063132753.1  troponin T, slow skeletal muscle isoform X3

    5. XM_063276702.1XP_063132772.1  troponin T, slow skeletal muscle isoform X4

    6. XM_063276768.1XP_063132838.1  troponin T, slow skeletal muscle isoform X7

    7. XM_063276789.1XP_063132859.1  troponin T, slow skeletal muscle isoform X8

    8. XM_063276811.1XP_063132881.1  troponin T, slow skeletal muscle isoform X9

      UniProtKB/TrEMBL
      A6KNL7
    9. XM_063276664.1XP_063132734.1  troponin T, slow skeletal muscle isoform X2

    10. XM_063276839.1XP_063132909.1  troponin T, slow skeletal muscle isoform X10

      UniProtKB/TrEMBL
      A6KNL7
      Related
      ENSRNOP00000076828.2, ENSRNOT00000101852.2
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