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    Fkbp11 FKBP prolyl isomerase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300211, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fkbp11provided by RGD
    Official Full Name
    FKBP prolyl isomerase 11provided by RGD
    Primary source
    RGD:1306161
    See related
    EnsemblRapid:ENSRNOG00000054775 AllianceGenome:RGD:1306161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and regulation of transcription by RNA polymerase II. Predicted to be active in endoplasmic reticulum. Orthologous to human FKBP11 (FKBP prolyl isomerase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 54.8), Spleen (RPKM 30.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fkbp11 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131750828..131757784, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129871870..129877760, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140398253..140402664, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene uncharacterized LOC103692978 Neighboring gene Rho family GTPase 1 Neighboring gene coiled-coil domain containing 65 Neighboring gene ARF GTPase 3 Neighboring gene Wnt family member 10B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP11
    Names
    FK506 binding protein 11
    NP_001013123.2
    XP_006257406.1
    XP_063119446.1
    XP_063119447.1
    XP_063119448.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013105.2 → NP_001013123.2  peptidyl-prolyl cis-trans isomerase FKBP11 precursor

      See identical proteins and their annotated locations for NP_001013123.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KCA2, G3V7V5
      Related
      ENSRNOP00000072158.2, ENSRNOT00000083955.3
      Conserved Domains (1) summary
      pfam00254
      Location:50 → 141
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131750828..131757784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257344.5 → XP_006257406.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X1

      Conserved Domains (1) summary
      pfam00254
      Location:44 → 119
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. XM_063263378.1 → XP_063119448.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X2

      UniProtKB/TrEMBL
      A6KCA3

    3. XM_063263377.1 → XP_063119447.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X2

      UniProtKB/TrEMBL
      A6KCA3

    4. XM_063263376.1 → XP_063119446.1  peptidyl-prolyl cis-trans isomerase FKBP11 isoform X2

      UniProtKB/TrEMBL
      A6KCA3
    Nucleotide Protein Strain
    Heading Accession and Version

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