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    Plpp4 phospholipid phosphatase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plpp4provided by RGD
    Official Full Name
    phospholipid phosphatase 4provided by RGD
    Primary source
    RGD:1306289
    See related
    EnsemblRapid:ENSRNOG00000020424 AllianceGenome:RGD:1306289
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ppapdc1a; RGD1306289
    Summary
    Predicted to enable diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and regulation of calcium ion import. Predicted to act upstream of or within blastocyst hatching. Predicted to be active in membrane. Orthologous to human PLPP4 (phospholipid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 36.0), Lung (RPKM 24.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plpp4 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (193260181..193389659)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (183829794..183959319)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (202432366..202560628)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349652 Neighboring gene uncharacterized LOC134484913 Neighboring gene uncharacterized LOC134485180 Neighboring gene presenilin associated, rhomboid-like, pseudogene 1 Neighboring gene uncharacterized LOC120098013

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca(2+)-permeable Cationic Channel in lung carcinoma cells. Zhang X, et al. Mol Cancer, 2017 Aug 29. PMID 28851360, Free PMC Article
    2. Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer. Dahl E, et al. Clin Cancer Res, 2006 Jul 1. PMID 16818692
    3. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. Takeuchi M, et al. Gene, 2007 Sep 15. PMID 17590538
    4. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables diacylglycerol diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase 4
    Names
    phosphatidate phosphatase PPAPDC1A
    phosphatidic acid phosphatase type 2 domain containing 1A
    NP_001178560.1
    XP_017444709.1
    XP_038934456.1
    XP_038934461.1
    XP_038934467.1
    XP_063119499.1
    XP_063119505.1
    XP_063119508.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191631.1 → NP_001178560.1  phospholipid phosphatase 4

      See identical proteins and their annotated locations for NP_001178560.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LZ94
      Related
      ENSRNOP00000027681.6, ENSRNOT00000027681.8
      Conserved Domains (1) summary
      cd03390
      Location:37 → 225
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      193260181..193389659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078528.2 → XP_038934456.1  phospholipid phosphatase 4 isoform X2

      Conserved Domains (1) summary
      cd03390
      Location:37 → 206
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    2. XM_039078539.2 → XP_038934467.1  phospholipid phosphatase 4 isoform X5

      Conserved Domains (1) summary
      cl00474
      Location:37 → 144
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    3. XM_063263429.1 → XP_063119499.1  phospholipid phosphatase 4 isoform X1

      Related
      ENSRNOP00000099087.1, ENSRNOT00000145246.1

    4. XM_039078533.2 → XP_038934461.1  phospholipid phosphatase 4 isoform X4

      Conserved Domains (1) summary
      cd03390
      Location:37 → 168
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    5. XM_017589220.2 → XP_017444709.1  phospholipid phosphatase 4 isoform X6

      Conserved Domains (1) summary
      cl00474
      Location:37 → 162
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    6. XM_063263435.1 → XP_063119505.1  phospholipid phosphatase 4 isoform X3

    7. XM_063263438.1 → XP_063119508.1  phospholipid phosphatase 4 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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