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    Esyt2 extended synaptotagmin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299488, updated on 9-Dec-2024

    Summary

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    Symbol
    Esyt2provided by RGD
    Full Name
    extended synaptotagmin 2provided by RGD
    Primary source
    RGD:1565705
    See related
    EnsemblRapid:ENSRNOG00000032391 AllianceGenome:RGD:1565705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565705
    Summary
    Predicted to enable calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 388.5), Lung (RPKM 273.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Esyt2 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143359870..143455600)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (137219653..137312590)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (144156021..144248374)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479489 Neighboring gene dynein 2 intermediate chain 1 Neighboring gene ribosomal protein L32, pseudogene 17 Neighboring gene uncharacterized LOC134479490 Neighboring gene non-SMC condensin II complex, subunit G2 Neighboring gene uncharacterized LOC102548847

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Schauder CM, et al. Nature, 2014 Jun 26. PMID 24847877, Free PMC Article
    2. Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2. Xu J, et al. Structure, 2014 Feb 4. PMID 24373768, Free PMC Article
    3. Visual properties of transgenic rats harboring the channelrhodopsin-2 gene regulated by the thy-1.2 promoter. Tomita H, et al. PLoS One, 2009 Nov 5. PMID 19893752, Free PMC Article
    4. E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Min SW, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360437, Free PMC Article
    5. Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides. Dickson EJ, et al. J Cell Biol, 2016 Apr 11. PMID 27044890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    extended synaptotagmin-2
    Names
    extended synaptotagmin protein 2
    extended synaptotagmin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271169.1 → NP_001258098.1  extended synaptotagmin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6KDL4, D3ZJ32
      Related
      ENSRNOP00000006582.7, ENSRNOT00000006582.9
      Conserved Domains (4) summary
      cd04030
      Location:710 → 835
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461 → 566
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309 → 429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      143359870..143455600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261796.1 → XP_063117866.1  extended synaptotagmin-2 isoform X1

    2. XM_039112112.2 → XP_038968040.1  extended synaptotagmin-2 isoform X4

      Related
      ENSRNOP00000099023.1, ENSRNOT00000145580.1
      Conserved Domains (4) summary
      cd04030
      Location:765 → 890
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461 → 621
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309 → 429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    3. XM_063261797.1 → XP_063117867.1  extended synaptotagmin-2 isoform X2

    4. XM_039112113.2 → XP_038968041.1  extended synaptotagmin-2 isoform X6

      Related
      ENSRNOP00000109126.1, ENSRNOT00000139772.1
      Conserved Domains (4) summary
      cd04030
      Location:744 → 869
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461 → 600
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309 → 429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    5. XM_063261798.1 → XP_063117868.1  extended synaptotagmin-2 isoform X3

    6. XM_039112114.2 → XP_038968042.1  extended synaptotagmin-2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A660
      Related
      ENSRNOP00000086527.1, ENSRNOT00000117706.2
      Conserved Domains (4) summary
      cd04030
      Location:731 → 856
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461 → 587
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309 → 429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    7. XM_063261799.1 → XP_063117869.1  extended synaptotagmin-2 isoform X5

    8. XM_039112119.2 → XP_038968047.1  extended synaptotagmin-2 isoform X10

      Conserved Domains (2) summary
      cd08391
      Location:309 → 429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    9. XM_039112120.2 → XP_038968048.1  extended synaptotagmin-2 isoform X11

      Conserved Domains (2) summary
      cd08391
      Location:309 → 429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    10. XM_063261800.1 → XP_063117870.1  extended synaptotagmin-2 isoform X8

    11. XM_063261801.1 → XP_063117871.1  extended synaptotagmin-2 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

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