Ltbp1 latent transforming growth factor beta binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ltbp1provided by RGD
Official Full Name: latent transforming growth factor beta binding protein 1provided by RGD
Primary source: RGD:68379
See related: EnsemblRapid:ENSRNOG00000033090 AllianceGenome:RGD:68379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including microfibril binding activity; receptor ligand inhibitor activity; and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of large latent transforming growth factor-beta complex. Biomarker of glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 310.7), Lung (RPKM 206.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q13

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (25781625..26177346, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (20029629..20425339, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (21203502..21600441, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LTBP-1 but not TGF-beta1 is induced by PDGF-BB and TGF-beta1 autoinduction does not affect the expression of LTBP-beta1
Title: PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line.
Mesangial expression of LTBP-1 and fibrillin-1 is induced early in experimental nephritis and LTBP-1 and fibrillin-1 are partially colocalized in the nephritic glomerulus.
Title: Induction and coexpression of latent transforming growth factor beta-binding protein-1 and fibrillin-1 in experimental glomerulonephritis.
fibronectin has a role in LTBP1 assembly in the ECM and in regulation of TGF beta via LTBP1 interactions
Title: Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.
observations suggest that latent transforming growth factor-beta binding protein-1 plays a critical role in intimal thickening of diabetic artery through the acceleration of smooth muscle cell migration via integrin-beta(3)
Title: Latent transforming growth factor-beta binding protein-1, a component of latent transforming growth factor-beta complex, accelerates the migration of aortic smooth muscle cells in diabetic rats through integrin-beta3.

Submit: New GeneRIF Correction

General gene information

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Markers

D6Rat39 (e-PCR)
- UniSTS:119601

AU028270 (e-PCR)
- UniSTS:116029

AU028823 (e-PCR)
- UniSTS:111952

RH141349 (e-PCR)
- UniSTS:223345

BE100782 (e-PCR)
- UniSTS:249851

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables microfibril binding	IBA Inferred from Biological aspect of Ancestor more info
enables microfibril binding	IEA Inferred from Electronic Annotation more info
enables microfibril binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand inhibitor activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand inhibitor activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transforming growth factor beta binding	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to extracellular region	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to extracellular region	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of TGFbeta in extracellular matrix	IEA Inferred from Electronic Annotation more info
involved_in sequestering of TGFbeta in extracellular matrix	ISO Inferred from Sequence Orthology more info
involved_in sequestering of TGFbeta in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of large latent transforming growth factor-beta complex	IDA Inferred from Direct Assay more info	PubMed
located_in microfibril	IEA Inferred from Electronic Annotation more info
located_in microfibril	ISO Inferred from Sequence Orthology more info
located_in microfibril	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: latent-transforming growth factor beta-binding protein 1

Names: LTBP-1; LanC (bacterial lantibiotic synthetase component C)-like 1; TGF-beta-1-BP-1; transforming growth factor beta-1-binding protein 1; transforming growth factor beta-1-masking protein large subunit; transforming growth factor-beta (TGF-beta) masking protein large subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021587.2 → NP_067598.2 latent-transforming growth factor beta-binding protein 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q00918

UniProtKB/TrEMBL

A6H9X2, D3ZAA3

Related

ENSRNOP00000040099.4, ENSRNOT00000047674.6

Conserved Domains (6) summary

smart00179
Location:1194 → 1235

EGF_CA; Calcium-binding EGF-like domain

PHA03247
Location:703 → 860

PHA03247; large tegument protein UL36; Provisional

cd00054
Location:990 → 1023

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:907 → 947

EGF_CA; Calcium-binding EGF domain

pfam00683
Location:681 → 722

TB; TB domain

pfam12662
Location:888 → 910

cEGF; Complement Clr-like EGF-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

25781625..26177346 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262385.1 → XP_063118455.1 latent-transforming growth factor beta-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q00918

UniProtKB/TrEMBL

A0A8I6AA33

Related

ENSRNOP00000088104.1, ENSRNOT00000101612.2
XM_063262388.1 → XP_063118458.1 latent-transforming growth factor beta-binding protein 1 isoform X4

UniProtKB/Swiss-Prot

Q00918
XM_063262387.1 → XP_063118457.1 latent-transforming growth factor beta-binding protein 1 isoform X3

UniProtKB/Swiss-Prot

Q00918

UniProtKB/TrEMBL

A0A8I5Y739

Related

ENSRNOP00000078120.1, ENSRNOT00000112287.2
XM_063262386.1 → XP_063118456.1 latent-transforming growth factor beta-binding protein 1 isoform X2

UniProtKB/Swiss-Prot

Q00918
XM_063262389.1 → XP_063118459.1 latent-transforming growth factor beta-binding protein 1 isoform X5

UniProtKB/Swiss-Prot

Q00918
XM_063262390.1 → XP_063118460.1 latent-transforming growth factor beta-binding protein 1 isoform X6
XM_063262393.1 → XP_063118463.1 latent-transforming growth factor beta-binding protein 1 isoform X9
XM_063262392.1 → XP_063118462.1 latent-transforming growth factor beta-binding protein 1 isoform X8
XM_063262391.1 → XP_063118461.1 latent-transforming growth factor beta-binding protein 1 isoform X7

UniProtKB/Swiss-Prot

Q00918