Kcnn3 potassium calcium-activated channel subfamily N member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnn3provided by RGD
Official Full Name: potassium calcium-activated channel subfamily N member 3provided by RGD
Primary source: RGD:2964
See related: EnsemblRapid:ENSRNOG00000020706 AllianceGenome:RGD:2964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SK3; KCa2.3
Summary: Enables small conductance calcium-activated potassium channel activity. Involved in potassium ion transport. Located in filopodium; neuromuscular junction; and neuronal cell body. Human ortholog(s) of this gene implicated in paranoid schizophrenia and schizophrenia. Orthologous to human KCNN3 (potassium calcium-activated channel subfamily N member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 56.8), Heart (RPKM 50.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177227276..177378849)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (174929846..175088910)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (188837280..188991794)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of SK3 channel plays a pivotal role in modulation of trigeminal neuralgia.
Title: Activation of SK3 channel plays a pivotal role in modulation of trigeminal neuralgia.
Reduced expression and activity of SK channels in the detrusor smooth muscle contribute to Obesity-related Overactive Bladder.
Title: Effect of high-fat diet-induced obesity on the small-conductance Ca(2+)-activated K(+) channel function affecting the contractility of rat detrusor smooth muscle.
expression significantly decreased in the penile corpus cavernosum of castrated groups, and expression positively correlated with level of androgen
Title: Effect of low androgen levels on IKca and SKca3 channels in rat penile corpus cavernosum.
The hypotensive effect of FAAH inhibitor URB597 is independent of KCa2.3/KCa3.1-endothelium dependent hyperpolarization-type relaxation.
Title: The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on K(Ca)2.3/K(Ca)3.1-EDH-type relaxation in rat small mesenteric arteries.
SK3 was found in ventricular myocyte mitochondria. Agonists protected against ischemia-reperfusion injury in vivo.
Title: Identity and function of a cardiac mitochondrial small conductance Ca(2+)-activated K(+) channel splice variant.
SK3 doesn't contribute to the enhanced ability of microglia to migrate and invade when in anti-inflammatory states.
Title: Expression and contributions of TRPM7 and KCa2.3/SK3 channels to the increased migration and invasion of microglia in anti-inflammatory activation states.
Whole-cell measurements of PC12 cells transfected with Endophilin A3 showed a reduction of KCa2.3 specific Cs(+) currents indicating that the interaction of Endophilin A3 with K(Ca)2.3 channels also occurs in mammalian cells
Title: Evidence for the interaction of endophilin a3 with endogenous Kca2.3 channels in PC12 cells.
the hormonal effect on SK3 caused by 17beta-estradiol includes divergent regulation at mRNA and protein levels.
Title: Expression of the small conductance Ca²⁺-activated potassium channel subtype 3 (SK3) in rat uterus after stimulation with 17β-estradiol.
SK3 strongly increased during postnatal development and maintained throughout postnatal development and in the adult brain
Title: Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system.
Data suggest that down-regulation of Kcnn3 in vascular endothelium in both male and female offspring of pregnant rats with elevated blood levels of testosterone/androgen (as in pre-eclampsia) may be involved in development of hypertension.
Title: Prenatal testosterone induces sex-specific dysfunction in endothelium-dependent relaxation pathways in adult male and female rats.

Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Markers

G16005 (e-PCR)
- UniSTS:43402

D2Wox58 (e-PCR)
- UniSTS:240055

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables small conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables small conductance calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables small conductance calcium-activated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables small conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small conductance calcium-activated potassium channel protein 3

Names: SKCa 3; SKCa3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; small-conductance Ca2+-activated K+ channel 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019315.3 → NP_062188.3 small conductance calcium-activated potassium channel protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P70605, Q9EQ81, Q9ERQ4

UniProtKB/TrEMBL

A6J6H0, G3V8S7

Related

ENSRNOP00000028117.5, ENSRNOT00000028117.7

Conserved Domains (4) summary

smart01053
Location:561 → 636

CaMBD; Calmodulin binding domain

pfam03530
Location:273 → 380

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:468 → 547

Ion_trans_2; Ion channel

cl09111
Location:601 → 673

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

177227276..177378849

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282418.1 → XP_063138488.1 small conductance calcium-activated potassium channel protein 3 isoform X1

UniProtKB/Swiss-Prot

P70605, Q9EQ81, Q9ERQ4

UniProtKB/TrEMBL

A6J6H0, G3V8S7
XM_017591053.3 → XP_017446542.1 small conductance calcium-activated potassium channel protein 3 isoform X2

Conserved Domains (4) summary

smart01053
Location:248 → 323

CaMBD; Calmodulin binding domain

pfam03530
Location:1 → 67

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:155 → 234

Ion_trans_2; Ion channel

cl09111
Location:288 → 360

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_039102986.2 → XP_038958914.1 small conductance calcium-activated potassium channel protein 3 isoform X2

Conserved Domains (4) summary

smart01053
Location:248 → 323

CaMBD; Calmodulin binding domain

pfam03530
Location:1 → 67

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:155 → 234

Ion_trans_2; Ion channel

cl09111
Location:288 → 360

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...