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    Rab2a RAB2A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65158, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab2aprovided by RGD
    Official Full Name
    RAB2A, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:68323
    See related
    EnsemblRapid:ENSRNOG00000005963 AllianceGenome:RGD:68323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rab2
    Summary
    Enables GTP binding activity. Predicted to be involved in Golgi organization; macroautophagy; and vesicle-mediated transport. Located in several cellular components, including Golgi membrane; neuronal cell body; and perinuclear region of cytoplasm. Is active in synaptic vesicle membrane. Orthologous to human RAB2A (RAB2A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 713.1), Kidney (RPKM 561.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rab2a in Genome Data Viewer
    Location:
    5q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (26473424..26537441)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (21676017..21740035)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (21632654..21696721)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350928 Neighboring gene uncharacterized LOC102551006 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134486917 Neighboring gene chromodomain helicase DNA binding protein 7 Neighboring gene uncharacterized LOC108350929

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding  
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    Process Evidence Code Pubs
    involved_in Golgi organization  
    involved_in Golgi organization  
    involved_in Golgi organization  
    involved_in Rab protein signal transduction PubMed 
    NOT involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in macroautophagy  
    involved_in macroautophagy  
    involved_in protein transport  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    is_active_in Golgi membrane  
    located_in Golgi membrane PubMed 
    located_in Golgi membrane  
    located_in acrosomal vesicle  
    located_in autophagosome membrane  
    located_in autophagosome membrane  
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane  
    located_in melanosome  
    located_in membrane PubMed 
    located_in neuronal cell body PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    ras-related protein Rab-2A
    Names
    RAB2, member RAS oncogene family
    NP_113906.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031718.2NP_113906.2  ras-related protein Rab-2A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P05712
      UniProtKB/TrEMBL
      A0A8I6A522
      Related
      ENSRNOP00000088413.1, ENSRNOT00000112446.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      26473424..26537441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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