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    Sun2 Sad1 and UNC84 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315135, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sun2provided by RGD
    Official Full Name
    Sad1 and UNC84 domain containing 2provided by RGD
    Primary source
    RGD:1563141
    See related
    EnsemblRapid:ENSRNOG00000015177 AllianceGenome:RGD:1563141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Unc84b; RGD1563141
    Summary
    Predicted to enable cytoskeleton-nuclear membrane anchor activity; identical protein binding activity; and lamin binding activity. Predicted to be involved in several processes, including centrosome localization; nuclear matrix anchoring at nuclear membrane; and nuclear migration. Predicted to be located in chromosome, telomeric region; condensed nuclear chromosome; and nuclear inner membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Orthologous to human SUN2 (Sad1 and UNC84 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 326.6), Muscle (RPKM 280.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sun2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113155766..113172950, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111275374..111292565, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120950391..120967583, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Josephin domain containing 1 Neighboring gene GTP binding protein 1 Neighboring gene dynein, axonemal, light chain 4 Neighboring gene neuronal pentraxin receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeleton-nuclear membrane anchor activity  
    enables identical protein binding  
    enables lamin binding  
    enables protein-membrane adaptor activity  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region  
    located_in condensed nuclear chromosome  
    part_of meiotic nuclear membrane microtubule tethering complex  
    part_of meiotic nuclear membrane microtubule tethering complex  
    is_active_in nuclear envelope  
    located_in nuclear envelope  
    located_in nuclear inner membrane  
    located_in nuclear membrane  

    General protein information

    Preferred Names
    SUN domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427688.1NP_001414617.1  SUN domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A6J5, A6HST7
      Related
      ENSRNOP00000088618.1, ENSRNOT00000110877.2
    2. NM_001427689.1NP_001414618.1  SUN domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A6J5, D3ZTT7
    3. NM_001427690.1NP_001414619.1  SUN domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A6J5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      113155766..113172950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242047.5XP_006242109.1  SUN domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006242109.1

      UniProtKB/TrEMBL
      A0A8I6A6J5
      Related
      ENSRNOP00000044360.5, ENSRNOT00000046399.8
      Conserved Domains (1) summary
      pfam07738
      Location:584718
      Sad1_UNC; Sad1 / UNC-like C-terminal
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