U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Id4 inhibitor of DNA binding 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291023, updated on 9-Dec-2024

    Summary

    Official Symbol
    Id4provided by RGD
    Official Full Name
    inhibitor of DNA binding 4provided by RGD
    Primary source
    RGD:631428
    See related
    EnsemblRapid:ENSRNOG00000016099 AllianceGenome:RGD:631428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Idb4
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription corepressor activity; and transcription regulator inhibitor activity. Predicted to be involved in circadian rhythm; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to act upstream of or within several processes, including central nervous system development; gland morphogenesis; and negative regulation of cell differentiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ID4 (inhibitor of DNA binding 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 322.2), Liver (RPKM 173.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Id4 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (16595724..16598293, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (16389387..16391956, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (16692557..16695126, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097935 Neighboring gene uncharacterized LOC108348525 Neighboring gene microRNA let-7d Neighboring gene microRNA 3596b Neighboring gene zinc finger protein 169 Neighboring gene uncharacterized LOC120097866 Neighboring gene uncharacterized LOC134482825 Neighboring gene uncharacterized LOC108348527

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 33
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle  
    acts_upstream_of astrocyte differentiation  
    acts_upstream_of_or_within brain development  
    acts_upstream_of cell population proliferation  
    acts_upstream_of_or_within central nervous system myelination  
    acts_upstream_of_or_within cerebral cortex neuron differentiation  
    involved_in circadian rhythm  
    acts_upstream_of fat cell differentiation  
    acts_upstream_of_or_within fat cell differentiation  
    acts_upstream_of_or_within hippocampus development  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of_or_within negative regulation of astrocyte differentiation  
    acts_upstream_of_or_within negative regulation of fat cell differentiation  
    acts_upstream_of_or_within negative regulation of neuron differentiation  
    acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of neuroblast proliferation  
    acts_upstream_of_or_within neuroblast proliferation  
    involved_in neuron differentiation  
    acts_upstream_of neuron differentiation  
    acts_upstream_of oligodendrocyte differentiation  
    acts_upstream_of_or_within osteoblast differentiation  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of neuroblast proliferation  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within prostate gland epithelium morphogenesis  
    acts_upstream_of_or_within prostate gland morphogenesis  
    acts_upstream_of_or_within prostate gland stromal morphogenesis  
    acts_upstream_of_or_within protein localization  
    acts_upstream_of_or_within seminal vesicle morphogenesis  
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    DNA-binding protein inhibitor ID-4
    Names
    inhibitor of DNA binding 4, HLH protein
    inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175582.2NP_783172.2  DNA-binding protein inhibitor ID-4

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      E9PU21, Q8CH17
      Related
      ENSRNOP00000021550.2, ENSRNOT00000021550.4
      Conserved Domains (1) summary
      cd19694
      Location:62117
      bHLH_dnHLH_ID4; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      16595724..16598293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.