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    Sfxn5 sideroflexin 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 261737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sfxn5provided by RGD
    Official Full Name
    sideroflexin 5provided by RGD
    Primary source
    RGD:628706
    See related
    EnsemblRapid:ENSRNOG00000037871 AllianceGenome:RGD:628706
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BBG-TCC; SLC64A5
    Summary
    Enables citrate transmembrane transporter activity. Involved in citrate transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SFXN5 (sideroflexin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 296.6), Muscle (RPKM 62.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sfxn5 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119307692..119427531, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (117750213..117869826, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (116995238..117111548, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene sepiapterin reductase, pseudogene 1 Neighboring gene uncharacterized LOC120102324 Neighboring gene empty spiracles homeobox 1 Neighboring gene RAB11 family interacting protein 5 Neighboring gene argininosuccinate synthase 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel mitochondrial tricarboxylate carrier. Miyake S, et al. Biochem Biophys Res Commun, 2002 Jul 12. PMID 12150972
    2. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Kory N, et al. Science, 2018 Nov 16. PMID 30442778, Free PMC Article
    3. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identification and functional characterization and possible role in biosynthesis and bioenergetics in the brain
      Title: Identification and characterization of a novel mitochondrial tricarboxylate carrier.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables citrate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in citrate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sideroflexin-5
    Names
    solute carrier family 64 member 5
    tricarboxylate carrier BBG-TCC

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153298.1 → NP_695210.1  sideroflexin-5

      See identical proteins and their annotated locations for NP_695210.1

      Status: PROVISIONAL

      Source sequence(s)
      AB056724
      UniProtKB/Swiss-Prot
      Q8CFD0
      UniProtKB/TrEMBL
      A0A8I6AD84, A6IAR4
      Related
      ENSRNOP00000090953.1, ENSRNOT00000108130.2
      Conserved Domains (1) summary
      pfam03820
      Location:29 → 342
      Mtc; Tricarboxylate carrier

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      119307692..119427531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285637.1 → XP_063141707.1  sideroflexin-5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AN56
      Related
      ENSRNOP00000095029.1, ENSRNOT00000108504.2

    2. XM_063285639.1 → XP_063141709.1  sideroflexin-5 isoform X5

    3. XM_063285640.1 → XP_063141710.1  sideroflexin-5 isoform X6

    4. XM_063285641.1 → XP_063141711.1  sideroflexin-5 isoform X7

    5. XM_063285638.1 → XP_063141708.1  sideroflexin-5 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AD84

    6. XM_039107143.2 → XP_038963071.1  sideroflexin-5 isoform X2

      Conserved Domains (1) summary
      pfam03820
      Location:95 → 294
      Mtc; Tricarboxylate carrier

    7. XM_039107141.2 → XP_038963069.1  sideroflexin-5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD84
      Related
      ENSRNOP00000090263.2, ENSRNOT00000113204.2
      Conserved Domains (1) summary
      pfam03820
      Location:29 → 321
      Mtc; Tricarboxylate carrier

    8. XM_039107142.2 → XP_038963070.1  sideroflexin-5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD84
      Conserved Domains (1) summary
      pfam03820
      Location:29 → 321
      Mtc; Tricarboxylate carrier

    RNA

    1. XR_005503169.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFD0.1 GenPept UniProtKB/Swiss-Prot:Q8CFD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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