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    Crtc3 CREB regulated transcription coactivator 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365297, updated on 9-Dec-2024

    Summary

    Symbol
    Crtc3provided by RGD
    Full Name
    CREB regulated transcription coactivator 3provided by RGD
    Primary source
    RGD:1309666
    See related
    EnsemblRapid:ENSRNOG00000011975 AllianceGenome:RGD:1309666
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309666
    Summary
    Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to cAMP; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and regulation of DNA-templated transcription. Predicted to act upstream of or within energy homeostasis and negative regulation of lipid catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human CRTC3 (CREB regulated transcription coactivator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 76.1), Lung (RPKM 36.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Crtc3 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143962038..144064324, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134552830..134655929, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142398248..142500562, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483745 Neighboring gene uncharacterized LOC108349447 Neighboring gene BLM RecQ like helicase Neighboring gene uncharacterized LOC134483746 Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene zinc finger and SCAN domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP response element binding protein binding  
    enables transcription coactivator activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    CREB-regulated transcription coactivator 3
    Names
    CREB-regulated transcription coactivator 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427241.1NP_001414170.1  CREB-regulated transcription coactivator 3

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K1A6
      Related
      ENSRNOP00000071763.2, ENSRNOT00000089591.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143962038..144064324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229463.5XP_006229525.1  CREB-regulated transcription coactivator 3 isoform X1

      See identical proteins and their annotated locations for XP_006229525.1

      UniProtKB/TrEMBL
      A0A0G2K1A6
      Conserved Domains (3) summary
      pfam12884
      Location:1164
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:159320
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:544617
      TORC_C; Transducer of regulated CREB activity, C terminus
    2. XM_039101058.2XP_038956986.1  CREB-regulated transcription coactivator 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1A6, F1LVL6
      Related
      ENSRNOP00000015949.6, ENSRNOT00000015948.8
      Conserved Domains (3) summary
      pfam12884
      Location:1164
      TORC_N; Transducer of regulated CREB activity, N-terminus
      pfam12885
      Location:159308
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:532606
      TORC_C; Transducer of regulated CREB activity, C-terminus
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