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    Gria3 glutamate ionotropic receptor AMPA type subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29628, updated on 10-Dec-2024

    Summary

    Official Symbol
    Gria3provided by RGD
    Official Full Name
    glutamate ionotropic receptor AMPA type subunit 3provided by RGD
    Primary source
    RGD:70958
    See related
    EnsemblRapid:ENSRNOG00000007682 AllianceGenome:RGD:70958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GLUR3; GluA3; GluR-3; GluR-C; GluR-K3
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Adrenal (RPKM 265.0), Brain (RPKM 192.4) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Gria3 in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (125103975..125369690)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (120238515..120504106)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (127561843..127829763)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene SET nuclear oncogene-like Neighboring gene ribosomal protein S27, pseudogene 5 Neighboring gene uncharacterized LOC134484131 Neighboring gene eukaryotic translation initiation factor 3, subunit K, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity  
    enables AMPA glutamate receptor activity PubMed 
    enables AMPA glutamate receptor activity  
    enables AMPA glutamate receptor activity  
    enables amyloid-beta binding PubMed 
    enables glutamate-gated calcium ion channel activity PubMed 
    enables glutamate-gated receptor activity PubMed 
    enables glutamate-gated receptor activity  
    enables ligand-gated monoatomic ion channel activity  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
    enables protein binding PubMed 
    enables signaling receptor activity  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling  
    involved_in ionotropic glutamate receptor signaling pathway  
    involved_in long-term synaptic potentiation  
    involved_in long-term synaptic potentiation  
    involved_in long-term synaptic potentiation  
    involved_in modulation of chemical synaptic transmission  
    involved_in monoatomic ion transmembrane transport  
    involved_in protein heterotetramerization  
    involved_in protein heterotetramerization  
    involved_in protein heterotetramerization  
    involved_in protein homotetramerization  
    involved_in protein homotetramerization  
    involved_in protein homotetramerization  
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of presynaptic membrane potential  
    involved_in regulation of receptor recycling PubMed 
    involved_in response to fungicide PubMed 
    involved_in response to lithium ion PubMed 
    involved_in synaptic transmission, glutamatergic  
    Items 1 - 20 of 30
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex  
    part_of AMPA glutamate receptor complex PubMed 
    part_of AMPA glutamate receptor complex  
    part_of AMPA glutamate receptor complex  
    located_in asymmetric synapse PubMed 
    located_in dendrite PubMed 
    located_in dendritic shaft PubMed 
    is_active_in dendritic spine  
    located_in dendritic spine PubMed 
    is_active_in glutamatergic synapse PubMed 
    part_of ionotropic glutamate receptor complex PubMed 
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in parallel fiber to Purkinje cell synapse  
    is_active_in parallel fiber to Purkinje cell synapse  
    located_in perikaryon PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density PubMed 
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane PubMed 
    is_active_in postsynaptic membrane PubMed 
    located_in postsynaptic membrane PubMed 
    located_in postsynaptic membrane  
    located_in postsynaptic membrane  
    is_active_in presynaptic active zone membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    part_of protein-containing complex PubMed 
    located_in synaptic cleft PubMed 
    located_in terminal bouton PubMed 
    Items 1 - 20 of 30

    General protein information

    Preferred Names
    glutamate receptor 3
    Names
    AMPA-selective glutamate receptor 3
    glutamate receptor, ionotrophic, AMPA 3
    glutamate receptor, ionotropic, AMPA 3
    glutamate receptor, ionotropic, AMPA3 (alpha 3)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112742.1NP_001106213.1  glutamate receptor 3 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences from isoform 1. RNA editing (AGA->GGA) changes Arg769Gly.
      Source sequence(s)
      BC091324, BF559208, BQ205510, CB713194, DV723256, EV762496, JAXUCZ010000021, M85036, X54656
      UniProtKB/Swiss-Prot
      P19492
      Conserved Domains (4) summary
      cd06387
      Location:29400
      PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
      cd13715
      Location:416799
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548829
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:40383
      ANF_receptor; Receptor family ligand binding region
    2. NM_032990.2NP_116785.2  glutamate receptor 3 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg769Gly.
      Source sequence(s)
      BC091324, BF559208, BQ205510, CB713194, DV723256, EV762496, JAXUCZ010000021, X54656
      UniProtKB/Swiss-Prot
      P19492
      Related
      ENSRNOP00000031170.7, ENSRNOT00000029031.9
      Conserved Domains (4) summary
      cd06387
      Location:29400
      PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
      cd13715
      Location:416799
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548829
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:40383
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      125103975..125369690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601951.3XP_017457440.1  glutamate receptor 3 isoform X2

      UniProtKB/Swiss-Prot
      P19492
      UniProtKB/TrEMBL
      A6JML6, G3V8Y9
      Related
      ENSRNOP00000098984.1, ENSRNOT00000169900.1
      Conserved Domains (4) summary
      cd06387
      Location:29400
      PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
      cd13715
      Location:416799
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548829
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:40383
      ANF_receptor; Receptor family ligand binding region
    2. XM_006257501.5XP_006257563.1  glutamate receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006257563.1

      UniProtKB/Swiss-Prot
      P19492
      UniProtKB/TrEMBL
      A6JML7, G3V6Z5
      Related
      ENSRNOP00000010367.6, ENSRNOT00000010367.8
      Conserved Domains (4) summary
      cd06387
      Location:29400
      PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
      cd13715
      Location:416799
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548829
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:40383
      ANF_receptor; Receptor family ligand binding region
    3. XM_006257496.5XP_006257558.1  glutamate receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006257558.1

      UniProtKB/Swiss-Prot
      P19492
      UniProtKB/TrEMBL
      A6JML7, G3V6Z5
      Conserved Domains (4) summary
      cd06387
      Location:29400
      PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
      cd13715
      Location:416799
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548829
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:40383
      ANF_receptor; Receptor family ligand binding region
    4. XM_017601950.3XP_017457439.1  glutamate receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      P19492
      UniProtKB/TrEMBL
      A6JML7, G3V6Z5
      Conserved Domains (4) summary
      cd06387
      Location:29400
      PBP1_iGluR_AMPA_GluR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR3 subunit of the AMPA receptor
      cd13715
      Location:416799
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548829
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:40383
      ANF_receptor; Receptor family ligand binding region

    RNA

    1. XR_005497951.2 RNA Sequence

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