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    Afg1l AFG1 like ATPase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Afg1lprovided by RGD
    Official Full Name
    AFG1 like ATPaseprovided by RGD
    Primary source
    RGD:1561501
    See related
    EnsemblRapid:ENSRNOG00000043033 AllianceGenome:RGD:1561501
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lace1
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial protein catabolic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Orthologous to human AFG1L (AFG1 like ATPase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 101.3), Heart (RPKM 80.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Afg1l in Genome Data Viewer
    Location:
    20q13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (47380582..47550307, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (45798344..45967997, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (47038824..47208812, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555657 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene forkhead box O3 Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene sorting nexin 3 Neighboring gene nuclear receptor subfamily 2, group E, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. Cesnekova J, et al. Oncotarget, 2016 Jul 26. PMID 27323408, Free PMC Article
    2. The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits. Cesnekova J, et al. Biochem J, 2016 Mar 15. PMID 26759378
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124994

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AFG1-like ATPase
    Names
    lactation elevated 1
    lactation elevated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037656.1 → NP_001032745.1  AFG1-like ATPase

      See identical proteins and their annotated locations for NP_001032745.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107937
      UniProtKB/Swiss-Prot
      Q32PX9
      UniProtKB/TrEMBL
      A0A8I5ZXV9
      Related
      ENSRNOP00000082827.1, ENSRNOT00000076620.3
      Conserved Domains (2) summary
      COG1485
      Location:73 → 471
      YhcM; Predicted ATPase [General function prediction only]
      cl21455
      Location:75 → 471
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      47380582..47550307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099033.2 → XP_038954961.1  AFG1-like ATPase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXV9
      Related
      ENSRNOP00000105556.1, ENSRNOT00000155260.1
      Conserved Domains (1) summary
      COG1485
      Location:60 → 458
      YhcM; Predicted ATPase [General function prediction only]

    2. XM_063279481.1 → XP_063135551.1  AFG1-like ATPase isoform X8

    3. XM_039099037.2 → XP_038954965.1  AFG1-like ATPase isoform X6

      UniProtKB/TrEMBL
      A6K6Z0
      Conserved Domains (1) summary
      cl38936
      Location:73 → 272
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_039099038.2 → XP_038954966.1  AFG1-like ATPase isoform X7

      UniProtKB/TrEMBL
      A6K6Z0
      Conserved Domains (1) summary
      cl38936
      Location:73 → 270
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_063279475.1 → XP_063135545.1  AFG1-like ATPase isoform X1

    6. XM_063279477.1 → XP_063135547.1  AFG1-like ATPase isoform X3

    7. XM_063279476.1 → XP_063135546.1  AFG1-like ATPase isoform X3

    8. XM_063279478.1 → XP_063135548.1  AFG1-like ATPase isoform X4

    9. XM_063279479.1 → XP_063135549.1  AFG1-like ATPase isoform X5

    RNA

    1. XR_005497332.2 RNA Sequence

    2. XR_010060756.1 RNA Sequence

    3. XR_005497334.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32PX9.1 GenPept UniProtKB/Swiss-Prot:Q32PX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials