Recql4 RecQ like helicase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Recql4provided by RGD
Official Full Name: RecQ like helicase 4provided by RGD
Primary source: RGD:1307732
See related: EnsemblRapid:ENSRNOG00000032446 AllianceGenome:RGD:1307732
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity and DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination; and telomeric D-loop disassembly. Predicted to act upstream of or within several processes, including negative regulation of sister chromatid cohesion; positive regulation of cell population proliferation; and skeletal system morphogenesis. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be active in chromosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Baller-Gerold syndrome; Rothmund-Thomson syndrome; and rapadilino syndrome. Orthologous to human RECQL4 (RecQ like helicase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 35.5), Thymus (RPKM 26.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (110304092..110311426, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (108423453..108430790, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117765892..117773128, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH141373 (e-PCR)
- UniSTS:223369

BE109516 (e-PCR)
- UniSTS:248279

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables 3'-5' DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA/DNA annealing activity	ISO Inferred from Sequence Orthology more info
enables bubble DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables oxidized purine DNA binding	ISO Inferred from Sequence Orthology more info
enables telomeric D-loop binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomeric D-loop disassembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent DNA helicase Q4

Names: RecQ helicase-like 4; RecQ protein-like 4

NP_001123966.1

EC 3.6.4.12

XP_006241868.1

EC 3.6.4.12

XP_008763788.1

EC 3.6.4.12

XP_008763789.1

EC 3.6.4.12

XP_038934760.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130494.1 → NP_001123966.1 ATP-dependent DNA helicase Q4

See identical proteins and their annotated locations for NP_001123966.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A6HSC9, D4A5W5

Related

ENSRNOP00000099781.1, ENSRNOT00000129887.1

Conserved Domains (4) summary

smart00343
Location:394 → 408

ZnF_C2HC; zinc finger

smart00487
Location:490 → 693

DEXDc; DEAD-like helicases superfamily

cd00079
Location:707 → 839

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:499 → 672

DEAD; DEAD/DEAH box helicase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

110304092..110311426 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078832.2 → XP_038934760.1 ATP-dependent DNA helicase Q4 isoform X4

UniProtKB/TrEMBL

D4A5W5

Conserved Domains (4) summary

smart00343
Location:394 → 408

ZnF_C2HC; zinc finger

cd18794
Location:660 → 804

SF2_C_RecQ; C-terminal helicase domain of the RecQ family helicases

cd18018
Location:452 → 654

DEXHc_RecQ4-like; DEAH-box helicase domain of RecQ4 and similar proteins

cd22289
Location:2 → 50

RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins
XM_006241806.4 → XP_006241868.1 ATP-dependent DNA helicase Q4 isoform X3

UniProtKB/TrEMBL

D4A5W5

Related

ENSRNOP00000047177.4, ENSRNOT00000045135.6

Conserved Domains (4) summary

smart00343
Location:394 → 408

ZnF_C2HC; zinc finger

smart00487
Location:491 → 694

DEXDc; DEAD-like helicases superfamily

cd00079
Location:708 → 840

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:500 → 673

DEAD; DEAD/DEAH box helicase
XM_008765567.3 → XP_008763789.1 ATP-dependent DNA helicase Q4 isoform X2

UniProtKB/TrEMBL

D4A5W5

Conserved Domains (4) summary

smart00343
Location:394 → 408

ZnF_C2HC; zinc finger

smart00487
Location:496 → 699

DEXDc; DEAD-like helicases superfamily

cd00079
Location:713 → 845

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:505 → 678

DEAD; DEAD/DEAH box helicase
XM_008765566.3 → XP_008763788.1 ATP-dependent DNA helicase Q4 isoform X1

UniProtKB/TrEMBL

D4A5W5

Conserved Domains (4) summary

smart00343
Location:394 → 408

ZnF_C2HC; zinc finger

smart00487
Location:497 → 700

DEXDc; DEAD-like helicases superfamily

cd00079
Location:714 → 846

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:506 → 679

DEAD; DEAD/DEAH box helicase