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    Cilk1 ciliogenesis associated kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84411, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cilk1provided by RGD
    Official Full Name
    ciliogenesis associated kinase 1provided by RGD
    Primary source
    RGD:71050
    See related
    EnsemblRapid:ENSRNOG00000008691 AllianceGenome:RGD:71050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ick
    Summary
    Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome and juvenile myoclonic epilepsy 10. Orthologous to human CILK1 (ciliogenesis associated kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 25.7), Kidney (RPKM 24.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cilk1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87868294..87922995)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (78984075..79042695)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85413998..85473374)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 10 Neighboring gene f-box protein 9 Neighboring gene ribosomal protein L12, pseudogene 1 Neighboring gene glutathione S-transferase alpha 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in intraciliary anterograde transport  
    involved_in intraciliary anterograde transport  
    involved_in intraciliary anterograde transport  
    involved_in intraciliary retrograde transport  
    involved_in intraciliary retrograde transport  
    involved_in intraciliary retrograde transport  
    involved_in intraciliary transport  
    involved_in intraciliary transport  
    involved_in intraciliary transport  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    Component Evidence Code Pubs
    located_in ciliary basal body  
    located_in ciliary basal body  
    located_in ciliary basal body  
    located_in ciliary base  
    located_in ciliary base  
    located_in ciliary base  
    located_in ciliary tip  
    located_in ciliary tip  
    located_in ciliary tip  
    is_active_in cilium  
    located_in cilium  
    located_in cilium  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in fibrillar center  
    located_in fibrillar center  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    serine/threonine-protein kinase ICK
    Names
    MAK-related kinase
    MRK
    heart serine-threonine protein kinase
    intestinal cell (MAK-like) kinase
    intestinal cell kinase
    NP_620241.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138886.1NP_620241.1  serine/threonine-protein kinase ICK

      See identical proteins and their annotated locations for NP_620241.1

      Status: PROVISIONAL

      Source sequence(s)
      D26178
      UniProtKB/Swiss-Prot
      Q62726
      UniProtKB/TrEMBL
      A6I1H7, G3V760
      Related
      ENSRNOP00000012257.5, ENSRNOT00000012257.8
      Conserved Domains (2) summary
      smart00220
      Location:4284
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      87868294..87922995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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