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    Sbk1 SH3 domain binding kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113907, updated on 9-Dec-2024

    Summary

    Symbol
    Sbk1provided by RGD
    Full Name
    SH3 domain binding kinase 1provided by RGD
    Primary source
    RGD:628713
    See related
    EnsemblRapid:ENSRNOG00000067387 AllianceGenome:RGD:628713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sbk
    Summary
    Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to be located in cytoplasm. Orthologous to human SBK1 (SH3 domain binding kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 247.9), Thymus (RPKM 95.7) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Sbk1 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190237677..190282494)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180807092..180851910)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197636230..197681031)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349639 Neighboring gene uncharacterized LOC120099931 Neighboring gene uncharacterized LOC108349640 Neighboring gene uncharacterized LOC102548820 Neighboring gene uncharacterized LOC134483833

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Component Evidence Code Pubs
    located_in cytoplasm  

    General protein information

    Preferred Names
    serine/threonine-protein kinase SBK1
    Names
    SH3-binding domain kinase 1
    SH3-binding kinase 1
    NP_671476.1
    XP_017444131.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_147135.3NP_671476.1  serine/threonine-protein kinase SBK1

      See identical proteins and their annotated locations for NP_671476.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      A2RRT7, Q9Z335
      UniProtKB/TrEMBL
      A0A8L2QDW4, A6I937
      Related
      ENSRNOP00000073472.2, ENSRNOT00000082228.3
      Conserved Domains (2) summary
      smart00220
      Location:53316
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13987
      Location:59317
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190237677..190282494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588642.3XP_017444131.1  serine/threonine-protein kinase SBK1 isoform X1

      UniProtKB/Swiss-Prot
      A2RRT7, Q9Z335
      UniProtKB/TrEMBL
      A0A8L2QDW4, A6I937
      Conserved Domains (2) summary
      smart00220
      Location:53316
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13987
      Location:59317
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1
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