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    Acyp2 acylphosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acyp2provided by RGD
    Official Full Name
    acylphosphatase 2provided by RGD
    Primary source
    RGD:1595836
    See related
    EnsemblRapid:ENSRNOG00000042419 AllianceGenome:RGD:1595836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable acylphosphatase activity and identical protein binding activity. Predicted to be located in mitochondrion. Orthologous to human ACYP2 (acylphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 393.7), Heart (RPKM 105.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acyp2 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (108402837..108572367, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (104201894..104371415, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (114891245..115052497, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096711 Neighboring gene ciliary microtubule inner protein 6 Neighboring gene uncharacterized LOC120096710 Neighboring gene peptidylprolyl isomerase D, pseudogene 4 Neighboring gene heterogeneous nuclear ribonucleoprotein K, pseudogene 5 Neighboring gene macrophage migration inhibitory factor, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation. Parrini C, et al. Structure, 2005 Aug. PMID 16084386
    2. Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases. Chiti F, et al. Proc Natl Acad Sci U S A, 2002 Dec 10. PMID 12374855, Free PMC Article
    3. Rat muscle acylphosphatase: purification, amino sequence, and immunological characterization. Berti A, et al. J Protein Chem, 1991 Feb. PMID 1647162
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acylphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acylphosphatase-2
    Names
    acylphosphatase 2, muscle type
    acylphosphatase, muscle type isozyme
    acylphosphatase-2-like
    acylphosphate phosphohydrolase 2
    NP_001162616.1
    XP_017454814.1
    XP_038948181.1
    XP_063129510.1
    XP_063129511.1
    XP_063129512.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169145.1 → NP_001162616.1  acylphosphatase-2

      See identical proteins and their annotated locations for NP_001162616.1

      Status: VALIDATED

      Source sequence(s)
      AW521357, CB613181, CO404339
      UniProtKB/TrEMBL
      A0A8I5ZKZ2, A6JQC8, D4A1G1
      Related
      ENSRNOP00000061028.2, ENSRNOT00000067998.4
      Conserved Domains (1) summary
      pfam00708
      Location:35 → 122
      Acylphosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      108402837..108572367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599325.3 → XP_017454814.1  acylphosphatase-2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AGK8
      Related
      ENSRNOP00000092926.1, ENSRNOT00000099667.2
      Conserved Domains (1) summary
      pfam00708
      Location:35 → 87
      Acylphosphatase

    2. XM_039092253.2 → XP_038948181.1  acylphosphatase-2 isoform X5

      UniProtKB/Swiss-Prot
      P35745
      Conserved Domains (1) summary
      pfam00708
      Location:6 → 83
      Acylphosphatase

    3. XM_063273441.1 → XP_063129511.1  acylphosphatase-2 isoform X2

    4. XM_063273442.1 → XP_063129512.1  acylphosphatase-2 isoform X3

    5. XM_063273440.1 → XP_063129510.1  acylphosphatase-2 isoform X1

    RNA

    1. XR_010057399.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35745.2 GenPept UniProtKB/Swiss-Prot:P35745

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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