Zbtb1 zinc finger and BTB domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zbtb1provided by RGD
Official Full Name: zinc finger and BTB domain containing 1provided by RGD
Primary source: RGD:1303095
See related: EnsemblRapid:ENSRNOG00000058593 AllianceGenome:RGD:1303095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; K63-linked polyubiquitin modification-dependent protein binding activity; and protein dimerization activity. Predicted to be involved in several processes, including mRNA transcription by RNA polymerase II; positive regulation of lymphocyte differentiation; and regulation of gene expression. Predicted to act upstream of or within B cell differentiation and T cell differentiation in thymus. Predicted to be located in nuclear body and nuclear membrane. Predicted to be active in nucleoplasm. Orthologous to human ZBTB1 (zinc finger and BTB domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 102.4), Spleen (RPKM 62.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (100832506..100864019)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (95096838..95125811)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (99401775..99425739)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH139658 (e-PCR)
- UniSTS:221742

AU047738 (e-PCR)
- UniSTS:110212

Zbtb1 (e-PCR), detects polymorphism
- UniSTS:515988

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pro-T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thymus development	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004444.2 → NP_001004444.1 zinc finger and BTB domain-containing protein 1 isoform 1

See identical proteins and their annotated locations for NP_001004444.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZRA2, E9PT64, Q672J3

Related

ENSRNOP00000081356.1, ENSRNOT00000119538.2

Conserved Domains (3) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:688 → 709

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:3 → 116

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
NM_001433970.1 → NP_001420899.1 zinc finger and BTB domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZRA2, E9PT64, Q672J3
NM_001433971.1 → NP_001420900.1 zinc finger and BTB domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K3D7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

100832506..100864019

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261928.1 → XP_063117998.1 zinc finger and BTB domain-containing protein 1 isoform X5
XM_006240241.5 → XP_006240303.1 zinc finger and BTB domain-containing protein 1 isoform X2

Conserved Domains (3) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:688 → 709

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:3 → 116

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
XM_006240243.5 → XP_006240305.1 zinc finger and BTB domain-containing protein 1 isoform X2

Conserved Domains (3) summary

sd00017
Location:580 → 600

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:688 → 709

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:3 → 116

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
XM_039112273.2 → XP_038968201.1 zinc finger and BTB domain-containing protein 1 isoform X3

Conserved Domains (2) summary

sd00017
Location:580 → 618

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:47 → 160

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
XM_039112274.2 → XP_038968202.1 zinc finger and BTB domain-containing protein 1 isoform X4

Conserved Domains (2) summary

sd00017
Location:580 → 618

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:47 → 160

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
XM_039112272.2 → XP_038968200.1 zinc finger and BTB domain-containing protein 1 isoform X1

Related

ENSRNOP00000080670.2, ENSRNOT00000117277.2

Conserved Domains (3) summary

sd00017
Location:624 → 644

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:732 → 753

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18192
Location:47 → 160

BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)