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    Caprin1 cell cycle associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362173, updated on 9-Dec-2024

    Summary

    Official Symbol
    Caprin1provided by RGD
    Official Full Name
    cell cycle associated protein 1provided by RGD
    Primary source
    RGD:1305707
    See related
    EnsemblRapid:ENSRNOG00000009152 AllianceGenome:RGD:1305707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpiap1; rng105; GPI p137
    Summary
    Enables RNA binding activity. Involved in negative regulation of translation. Located in P-body and cytoplasmic stress granule. Is active in glutamatergic synapse and postsynapse. Orthologous to human CAPRIN1 (cell cycle associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 882.7), Thymus (RPKM 757.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Caprin1 in Genome Data Viewer
    Location:
    3q32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (110606489..110685408, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (90152305..90230447, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (93701830..93789580, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101612 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene N-acetyltransferase 10 Neighboring gene uncharacterized LOC120101611 Neighboring gene uncharacterized LOC134486415 Neighboring gene uncharacterized LOC102549184 Neighboring gene cytochrome c oxidase subunit 4i1, pseudogene 1 Neighboring gene uncharacterized LOC120101615 Neighboring gene uncharacterized LOC102551977

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Clone Names

    • MGC124904, MGC125054

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP binding  
    enables RNA binding  
    enables RNA binding PubMed 
    enables mRNA binding  
    enables mRNA binding  
    enables molecular condensate scaffold activity  
    enables molecular condensate scaffold activity  
    enables molecular condensate scaffold activity  
    enables molecular function activator activity  
    enables molecular function activator activity  
    enables signaling adaptor activity  
    enables signaling adaptor activity  
    Process Evidence Code Pubs
    involved_in generation of neurons  
    acts_upstream_of_or_within generation of neurons  
    involved_in intracellular mRNA localization  
    acts_upstream_of_or_within intracellular mRNA localization  
    involved_in membraneless organelle assembly  
    involved_in membraneless organelle assembly  
    involved_in negative regulation of translation PubMed 
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    acts_upstream_of_or_within nervous system development  
    involved_in positive regulation of dendrite morphogenesis  
    involved_in positive regulation of dendrite morphogenesis  
    involved_in positive regulation of dendritic spine morphogenesis  
    involved_in positive regulation of dendritic spine morphogenesis  
    involved_in positive regulation of dendritic spine morphogenesis  
    involved_in positive regulation of stress granule assembly  
    involved_in positive regulation of stress granule assembly  
    involved_in positive regulation of stress granule assembly  
    involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA  
    involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA  
    involved_in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA  
    involved_in synapse assembly  
    acts_upstream_of_or_within synapse assembly  
    acts_upstream_of_or_within synapse organization  
    Component Evidence Code Pubs
    located_in P-body PubMed 
    located_in cell leading edge  
    located_in cell leading edge  
    located_in cell leading edge  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic stress granule PubMed 
    located_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    is_active_in dendrite  
    is_active_in glutamatergic synapse PubMed 
    is_active_in intracellular membraneless organelle  
    located_in lamellipodium  
    is_active_in postsynapse PubMed 
    located_in synapse  
    is_active_in synapse  

    General protein information

    Preferred Names
    caprin-1
    Names
    GPI-anchored membrane protein 1
    GPI-anchored protein p137
    GPI-p137
    RNA granule protein 105
    cytoplasmic activation- and proliferation-associated protein 1
    p137GPI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012185.3NP_001012185.2  caprin-1

      See identical proteins and their annotated locations for NP_001012185.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      A9ZSZ9, Q5M9G3, Q6YF16
      UniProtKB/TrEMBL
      A6HNS6
      Related
      ENSRNOP00000102792.1, ENSRNOT00000143989.1
      Conserved Domains (2) summary
      pfam12287
      Location:357679
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:130245
      Caprin-1_dimer; Caprin-1 dimerization domain
    2. NM_001423164.1NP_001410093.1  caprin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      A9ZSZ9, Q5M9G3, Q6YF16
      UniProtKB/TrEMBL
      A6HNS6
      Related
      ENSRNOP00000012428.8, ENSRNOT00000012428.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      110606489..110685408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284152.1XP_063140222.1  caprin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q6N7, A6HNS6
    2. XM_039105438.2XP_038961366.2  caprin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q6N7, A6HNS6
    3. XM_006234652.4XP_006234714.1  caprin-1 isoform X2

      UniProtKB/TrEMBL
      A6HNS6
      Conserved Domains (1) summary
      pfam12287
      Location:286598
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
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