Rbp1 retinol binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbp1provided by RGD
Official Full Name: retinol binding protein 1provided by RGD
Primary source: RGD:3543
See related: AllianceGenome:RGD:3543
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables retinol binding activity. Involved in response to benzoic acid; response to retinoic acid; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human RBP1 (retinol binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 917.6), Kidney (RPKM 594.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (107904589..107926109)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (99025218..99046740)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (106449321..106470842)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Retinal proteomic evaluation of rats following streptozotocininjection using shotgun proteomics.
Title: Retinal proteomic evaluation of rats following streptozotocin‑injection using shotgun proteomics.
CRBP1 contributes to pulmonary structural remodeling after myocardial infarction.
Title: [The role of cellular retinol-binding protein-1 on pulmonary structural remodeling after rat myocardial infarction].
a potential role of CRBP1 in the regulation of beta-catenin turnover which can greatly affect the process of osteogenesis and adipogenesis of mesenchymal stem cells
Title: Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXRα-induced β-catenin degradation.
As the convoluted proximal tubular epithelial cells dedifferentiate during fibrosis, CRBP-I expression decreases in adriamycin-induced fibrotic rat kidney.
Title: CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis.
analysis of conformational flexibility of rat cellular retinol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II)
Title: Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility.
Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution
Title: Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution.
CRBP1 has a role in vitamin A metabolism and its absence may play a role in ovarian cancer oncogenesis
Title: Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer.
differences in conformational flexibility between the ligand-free and ligand-bound forms of cellular retinol-binding protein type I
Title: Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinol binding	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol binding	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol binding	ISS Inferred from Sequence or Structural Similarity more info
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinol binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to benzoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	HEP more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to vitamin A	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin A metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin A metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: retinol-binding protein 1

Names: CRBP; CRBP-I; cellular retinol-binding protein I; retinol binding protein 1, cellular

NP_036865.1

EC 2.7.7.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012733.5 → NP_036865.1 retinol-binding protein 1

See identical proteins and their annotated locations for NP_036865.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P02696

Conserved Domains (1) summary

cd19462
Location:4 → 134

CRBP1; cellular retinol-binding protein 1