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    Nolc1 nucleolar and coiled-body phosphoprotein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64896, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nolc1provided by RGD
    Official Full Name
    nucleolar and coiled-body phosphoprotein 1provided by RGD
    Primary source
    RGD:621578
    See related
    EnsemblRapid:ENSRNOG00000018704 AllianceGenome:RGD:621578
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nopp140
    Summary
    Enables several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Involved in several processes, including box H/ACA sno(s)RNA metabolic process; positive regulation of DNA-templated transcription; and regulation of protein import into nucleus. Located in nucleolus and nucleoplasm. Part of box C/D methylation guide snoRNP complex and box H/ACA snoRNP complex. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 126.1), Brain (RPKM 118.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nolc1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254870195..254881070)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (244921275..244932089)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265829055..265839819)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene LIM domain binding 1 Neighboring gene LIM domain binding 1 like Neighboring gene PPARG related coactivator 1 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain 3 Neighboring gene ATP synthase membrane subunit g, pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis  
    involved_in box H/ACA sno(s)RNA metabolic process PubMed 
    involved_in neural crest cell development  
    involved_in neural crest cell development  
    involved_in neural crest cell development  
    involved_in neural crest formation  
    involved_in neural crest formation  
    involved_in neural crest formation  
    involved_in nucleolus organization  
    acts_upstream_of_or_within nucleolus organization  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in regulation of protein import into nucleus PubMed 
    acts_upstream_of_or_within regulation of synaptic plasticity  
    involved_in regulation of translation  
    involved_in regulation of translation  
    involved_in regulation of translation  
    Component Evidence Code Pubs
    located_in Cajal body  
    located_in Cajal body  
    part_of box C/D methylation guide snoRNP complex PubMed 
    part_of box H/ACA snoRNP complex PubMed 
    located_in cytoplasm  
    located_in fibrillar center  
    located_in fibrillar center  
    is_active_in nucleolus  
    located_in nucleolus PubMed 
    located_in nucleolus  
    is_active_in nucleoplasm  
    located_in nucleoplasm PubMed 
    located_in nucleoplasm  

    General protein information

    Preferred Names
    nucleolar and coiled-body phosphoprotein 1
    Names
    140 kDa nucleolar phosphoprotein
    nucleolar 130 kDa protein
    nucleolar phosphoprotein 140
    nucleolar phosphoprotein p130

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022869.2NP_074060.2  nucleolar and coiled-body phosphoprotein 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      F1LPS3, P41777
      UniProtKB/TrEMBL
      A0A8L2QDL7
      Related
      ENSRNOP00000025788.6, ENSRNOT00000025791.7
      Conserved Domains (2) summary
      PHA03247
      Location:147561
      PHA03247; large tegument protein UL36; Provisional
      pfam05022
      Location:629701
      SRP40_C; SRP40, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      254870195..254881070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272817.1XP_063128887.1  nucleolar and coiled-body phosphoprotein 1 isoform X2

      UniProtKB/TrEMBL
      A6JHK9
    2. XM_063272814.1XP_063128884.1  nucleolar and coiled-body phosphoprotein 1 isoform X1

      UniProtKB/TrEMBL
      A6JHK9
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