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    Slc5a2 solute carrier family 5 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64522, updated on 27-Dec-2024

    Summary

    Official Symbol
    Slc5a2provided by RGD
    Official Full Name
    solute carrier family 5 member 2provided by RGD
    Primary source
    RGD:620217
    See related
    EnsemblRapid:ENSRNOG00000020039 AllianceGenome:RGD:620217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sglt2
    Summary
    Enables D-glucose:sodium symporter activity. Involved in D-glucose transmembrane transport; negative regulation of urine volume; and renal potassium excretion. Located in brush border membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in familial renal glucosuria and renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1071.3) and Lung (RPKM 40.8) See more
    Orthologs
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    Genomic context

    See Slc5a2 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192277621..192283742)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182847185..182853309)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199682688..199688809)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 5 Neighboring gene transforming growth factor beta 1 induced transcript 1 Neighboring gene RUS family member 1 Neighboring gene alpha hemoglobin stabilizing protein Neighboring gene uncharacterized LOC120099940

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in D-glucose import across plasma membrane  
    involved_in D-glucose import across plasma membrane  
    involved_in D-glucose transmembrane transport PubMed 
    involved_in alpha-glucoside transport  
    involved_in alpha-glucoside transport  
    involved_in negative regulation of urine volume PubMed 
    involved_in renal D-glucose absorption  
    involved_in renal D-glucose absorption  
    involved_in renal D-glucose absorption  
    involved_in renal potassium excretion PubMed 
    involved_in sodium ion import across plasma membrane  
    involved_in sodium ion import across plasma membrane  
    involved_in sodium ion transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in brush border membrane PubMed 
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    sodium/glucose cotransporter 2
    Names
    Na(+)/glucose cotransporter 2
    low affinity Na-dependent glucose transporter (SGLT2)
    low affinity sodium-glucose cotransporter
    solute carrier family 5 (sodium/glucose cotransporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022590.2NP_072112.2  sodium/glucose cotransporter 2

      Status: VALIDATED

      Source sequence(s)
      AB070850, AB070976, U29881
      UniProtKB/Swiss-Prot
      P53792
      Related
      ENSRNOP00000027265.3, ENSRNOT00000027265.5
      Conserved Domains (1) summary
      cl00456
      Location:22670
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      192277621..192283742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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