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    Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64519, updated on 9-Dec-2024

    Summary

    Symbol
    Entpd1provided by RGD
    Full Name
    ectonucleoside triphosphate diphosphohydrolase 1provided by RGD
    Primary source
    RGD:69265
    See related
    EnsemblRapid:ENSRNOG00000014574 AllianceGenome:RGD:69265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ATP-DPH; NTPDase-1
    Summary
    Enables ADP phosphatase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to aluminum ion; cellular response to cytokine stimulus; and negative regulation of dopamine secretion. Located in several cellular components, including basolateral plasma membrane; synaptic membrane; and synaptic vesicle. Biomarker of demyelinating disease; hypothyroidism; intrahepatic cholestasis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 280.7), Uterus (RPKM 212.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Entpd1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (249374810..249502310)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (239425515..239552323)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (259692020..259818922)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 18 family, member A1 Neighboring gene microRNA mir-6317-1 Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 6 Neighboring gene tectonic family member 3 Neighboring gene uncharacterized LOC120097545 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene uncharacterized LOC134484043 Neighboring gene cyclin J

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables ADP phosphatase activity PubMed 
    enables ADP phosphatase activity  
    enables ATP binding  
    enables ATP hydrolysis activity PubMed 
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables CDP phosphatase activity  
    enables CTPase activity  
    enables DNA clamp loader activity  
    enables GDP phosphatase activity  
    enables IDP phosphatase activity  
    enables ITPase activity  
    enables UDP phosphatase activity  
    enables apyrase activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables hydrolase activity  
    enables identical protein binding PubMed 
    enables membrane scission GTPase motor activity  
    enables nucleoside diphosphate phosphatase activity PubMed 
    enables nucleoside diphosphate phosphatase activity  
    enables nucleoside diphosphate phosphatase activity  
    enables nucleoside diphosphate phosphatase activity  
    enables ribonucleoside triphosphate phosphatase activity  
    enables ribonucleoside triphosphate phosphatase activity PubMed 
    enables ribonucleoside triphosphate phosphatase activity  
    enables ribonucleoside triphosphate phosphatase activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in ADP catabolic process  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway  
    involved_in cellular response to aluminum ion PubMed 
    involved_in cellular response to interferon-alpha PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in negative regulation of ATP biosynthetic process PubMed 
    involved_in negative regulation of dopamine secretion PubMed 
    involved_in nucleoside diphosphate catabolic process  
    acts_upstream_of_or_within platelet activation  
    involved_in platelet aggregation  
    involved_in platelet aggregation  
    involved_in platelet aggregation  
    acts_upstream_of_or_within purine ribonucleoside diphosphate catabolic process  
    involved_in response to ATP PubMed 
    involved_in response to L-arginine PubMed 
    involved_in response to auditory stimulus PubMed 
    involved_in response to caffeine PubMed 
    involved_in response to gamma radiation PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to proline PubMed 
    Component Evidence Code Pubs
    located_in basement membrane  
    located_in basolateral plasma membrane PubMed 
    located_in caveola  
    located_in caveola  
    located_in caveola  
    located_in cell surface PubMed 
    is_active_in external side of plasma membrane  
    located_in extracellular space PubMed 
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in synaptic membrane PubMed 
    located_in synaptic vesicle PubMed 

    General protein information

    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 1
    Names
    ATP diphosphohydrolase
    ATPDase
    NTPDase 1
    NTPDase1
    ecto-ATP diphosphohydrolase 1
    ecto-ATPDase 1
    ecto-ATPase 1
    ecto-apyrase
    lymphoid cell activation antigen
    nucleoside triphosphate diphosphohydrolase 1
    NP_072109.2
    XP_017445154.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022587.2NP_072109.2  ectonucleoside triphosphate diphosphohydrolase 1

      See identical proteins and their annotated locations for NP_072109.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P97687
      UniProtKB/TrEMBL
      A6JH62, F1M0G3
      Related
      ENSRNOP00000051602.4, ENSRNOT00000054719.6
      Conserved Domains (1) summary
      pfam01150
      Location:40472
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      249374810..249502310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589665.3XP_017445154.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC0, A0A8I6AVT5
      Related
      ENSRNOP00000096959.1, ENSRNOT00000115846.2
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