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    Prokr2 prokineticin receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192649, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Prokr2provided by RGD
    Official Full Name
    prokineticin receptor 2provided by RGD
    Primary source
    RGD:708445
    See related
    EnsemblRapid:ENSRNOG00000082181 AllianceGenome:RGD:708445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr73l1
    Summary
    Enables G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to hormone stimulus; and circadian rhythm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 3 with or without anosmia. Orthologous to human PROKR2 (prokineticin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 11.1), Spleen (RPKM 2.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prokr2 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140077629..140092327, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (119624738..119639442, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125006180..125021020, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene uncharacterized LOC120101670 Neighboring gene glycerophosphocholine phosphodiesterase 1 Neighboring gene uncharacterized LOC102552951

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer's disease. Lattanzi R, et al. Neuropeptides, 2019 Feb. PMID 30553543
    2. Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons. Qiu CY, et al. J Neuroinflammation, 2012 May 29. PMID 22642848, Free PMC Article
    3. Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus. Masumoto KH, et al. Eur J Neurosci, 2006 Jun. PMID 16819985
    4. PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Monnier C, et al. Hum Mol Genet, 2009 Jan 1. PMID 18826963, Free PMC Article
    5. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Masuda Y, et al. Biochem Biophys Res Commun, 2002 Apr 26. PMID 12054613

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified a prokineticin receptor 2 (PKR2) splice variant, which lacking the second exon gives rise to a protein comprising only four transmembrane elements, denominated TM 4-7.
      Title: Identification and characterization of Prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer's disease.
    2. PK2 increases the activity of acid-sensing ion channels via the PK2 receptor and protein kinase C-dependent signal pathways in rat primary sensory neurons.
      Title: Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons.
    3. The results of this study suggested an intrinsic PK2 neurotransmission and functionally distinct roles for PKR2-expressing neurons in the SCN.
      Title: Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    prokineticin receptor 2
    Names
    G protein-coupled receptor 73-like 1
    G protein-coupled receptor I5E
    PK-R2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138978.2 → NP_620434.2  prokineticin receptor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8R415
      UniProtKB/TrEMBL
      A6HQG2, G3V8W3
      Related
      ENSRNOP00000105365.1, ENSRNOT00000170624.1
      Conserved Domains (1) summary
      cd15204
      Location:92 → 382
      7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      140077629..140092327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104229.2 → XP_038960157.1  prokineticin receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8R415
      UniProtKB/TrEMBL
      A6HQG2, G3V8W3
      Conserved Domains (1) summary
      cd15204
      Location:92 → 382
      7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R415.2 GenPept UniProtKB/Swiss-Prot:Q8R415

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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