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    S1pr1 sphingosine-1-phosphate receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29733, updated on 9-Dec-2024

    Summary

    Official Symbol
    S1pr1provided by RGD
    Official Full Name
    sphingosine-1-phosphate receptor 1provided by RGD
    Primary source
    RGD:61958
    See related
    EnsemblRapid:ENSRNOG00000013683 AllianceGenome:RGD:61958
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Edg1
    Summary
    Enables G protein-coupled receptor activity and sphingolipid binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of stress fiber assembly; and positive regulation of GTPase activity. Predicted to be located in external side of plasma membrane and nucleoplasm. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Used to study hypertension. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 299.1), Spleen (RPKM 279.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See S1pr1 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206309715..206314070, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (203624752..203629110, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (218654406..218658761, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L19 pseudogene Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102548358 Neighboring gene uncharacterized LOC120100612

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 46
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in T cell migration  
    involved_in T cell migration  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    involved_in angiogenesis  
    acts_upstream_of_or_within angiogenesis  
    involved_in blood vessel maturation  
    involved_in blood vessel maturation  
    acts_upstream_of_or_within brain development  
    involved_in cardiac muscle tissue growth involved in heart morphogenesis  
    involved_in cardiac muscle tissue growth involved in heart morphogenesis  
    involved_in cell migration  
    involved_in cell migration  
    acts_upstream_of cell population proliferation  
    involved_in chemotaxis  
    involved_in chemotaxis  
    involved_in endothelial cell differentiation PubMed 
    involved_in heart trabecula morphogenesis  
    involved_in heart trabecula morphogenesis  
    involved_in lamellipodium assembly  
    involved_in lamellipodium assembly  
    acts_upstream_of_or_within leukocyte chemotaxis  
    involved_in negative regulation of stress fiber assembly PubMed 
    involved_in neuron differentiation PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in positive regulation of GTPase activity PubMed 
    involved_in positive regulation of cell migration PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of positive chemotaxis PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of bone mineralization  
    involved_in regulation of bone mineralization  
    involved_in regulation of bone resorption  
    involved_in regulation of bone resorption  
    acts_upstream_of_or_within regulation of cell adhesion  
    involved_in regulation of metabolic process  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    involved_in transmission of nerve impulse PubMed 
    Items 1 - 25 of 46
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in endosome  
    located_in external side of plasma membrane  
    located_in intracellular membrane-bounded organelle  
    located_in membrane raft  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynapse  

    General protein information

    Preferred Names
    sphingosine 1-phosphate receptor 1
    Names
    EDG1 (Edg1)
    S1P receptor 1
    S1P receptor Edg-1
    S1P1
    endothelial differentiation G-protein coupled receptor 1
    endothelial differentiation sphingolipid G-protein-coupled receptor 1
    sphingosine 1-phosphate receptor Edg-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017301.2NP_058997.1  sphingosine 1-phosphate receptor 1

      See identical proteins and their annotated locations for NP_058997.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097938
      UniProtKB/Swiss-Prot
      P48303, Q4V7F6
      UniProtKB/TrEMBL
      A6HV78
      Related
      ENSRNOP00000098635.1, ENSRNOT00000142036.1
      Conserved Domains (1) summary
      cd15346
      Location:47323
      7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      206309715..206314070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761459.4XP_008759681.1  sphingosine 1-phosphate receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_008759681.1

      UniProtKB/Swiss-Prot
      P48303, Q4V7F6
      UniProtKB/TrEMBL
      A6HV78
      Related
      ENSRNOP00000052627.1, ENSRNOT00000018318.5
      Conserved Domains (1) summary
      cd15346
      Location:47323
      7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors
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