Ankra2 ankyrin repeat family A member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ankra2provided by RGD
Full Name: ankyrin repeat family A member 2provided by RGD
Primary source: RGD:1303108
See related: EnsemblRapid:ENSRNOG00000048118 AllianceGenome:RGD:1303108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ANKRA
Summary: Predicted to enable enzyme binding activity and low-density lipoprotein particle receptor binding activity. Predicted to be involved in regulation of protein-containing complex assembly. Predicted to be located in cytosol; membrane; and nucleus. Predicted to be part of 3M complex. Orthologous to human ANKRA2 (ankyrin repeat family A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 70.9), Kidney (RPKM 65.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (31347158..31358002)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (29612867..29623748)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (82407601..82418229, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANKRA could modulate the excitability of neurons by binding directly to endogenous BKCa channel and altering its gating kinetics in a calcium-dependent manner
Title: Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141618 (e-PCR)
- UniSTS:223612

AA891585 (e-PCR)
- UniSTS:261266

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of 3M complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat family A protein 2

Names: SLO-interacting ankyrin-containing protein; ankyrin repeat family A protein 2-like; ankyrin repeat, family A (RFXANK-like), 2; ankyrin-repeat family A protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416756.1 → NP_001403685.1 ankyrin repeat family A protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6I538, A6I539
NM_207595.2 → NP_997478.1 ankyrin repeat family A protein 2 isoform 1

See identical proteins and their annotated locations for NP_997478.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

M0R870, Q6Q287

Related

ENSRNOP00000107996.1, ENSRNOT00000147507.1

Conserved Domains (2) summary

sd00045
Location:181 → 212

ANK; ANK repeat [structural motif]

pfam12796
Location:186 → 276

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

31347158..31358002

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101921.2 → XP_038957849.1 ankyrin repeat family A protein 2 isoform X2

Conserved Domains (3) summary

COG0666
Location:52 → 252

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:128 → 159

ANK; ANK repeat [structural motif]

pfam12796
Location:133 → 223

Ank_2; Ankyrin repeats (3 copies)
XM_063281493.1 → XP_063137563.1 ankyrin repeat family A protein 2 isoform X1

Related

ENSRNOP00000098976.1, ENSRNOT00000136863.1
XM_063281494.1 → XP_063137564.1 ankyrin repeat family A protein 2 isoform X3