U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Mlip muscular LMNA-interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681849, updated on 9-Dec-2024

    Summary

    Symbol
    Mlipprovided by RGD
    Full Name
    muscular LMNA-interacting proteinprovided by RGD
    Primary source
    RGD:1590513
    See related
    EnsemblRapid:ENSRNOG00000005934 AllianceGenome:RGD:1590513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CIP
    Summary
    Predicted to enable lamin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body; nuclear envelope; and sarcolemma. Orthologous to human MLIP (muscular LMNA interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 263.0), Muscle (RPKM 150.0) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mlip in Genome Data Viewer
    Location:
    8q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (86815491..87085117, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (77935087..78204725, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (84409957..84634637, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480074 Neighboring gene U2 spliceosomal RNA Neighboring gene tubulointerstitial nephritis antigen Neighboring gene leucine rich repeat containing 1 Neighboring gene uncharacterized LOC120094211

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lamin binding  
    enables transcription corepressor activity  
    Component Evidence Code Pubs
    located_in PML body  
    located_in cytosol  
    located_in nuclear envelope  
    located_in nuclear lumen  
    located_in nucleus  
    located_in nucleus  
    located_in sarcolemma  

    General protein information

    Preferred Names
    muscular LMNA-interacting protein
    Names
    cardiac Isl1-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399373.1NP_001386302.1  muscular LMNA-interacting protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A096MJS3, A0A8I6AMD7
      Related
      ENSRNOP00000068241.1, ENSRNOT00000076213.4
      Conserved Domains (2) summary
      PHA03307
      Location:361614
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:566774
      MLIP; Muscular LMNA-interacting protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      86815491..87085117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082515.2XP_038938443.1  muscular LMNA-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (3) summary
      PHA03307
      Location:505758
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK10118
      Location:417584
      PRK10118; flagellar hook length control protein FliK
      pfam15274
      Location:710946
      MLIP; Muscular LMNA-interacting protein
    2. XM_039082514.2XP_038938442.1  muscular LMNA-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (3) summary
      PHA03307
      Location:505758
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK10118
      Location:417584
      PRK10118; flagellar hook length control protein FliK
      pfam15274
      Location:710946
      MLIP; Muscular LMNA-interacting protein
    3. XM_063266137.1XP_063122207.1  muscular LMNA-interacting protein isoform X18

    4. XM_063266135.1XP_063122205.1  muscular LMNA-interacting protein isoform X15

    5. XM_063266136.1XP_063122206.1  muscular LMNA-interacting protein isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZRC1
      Related
      ENSRNOP00000080719.1, ENSRNOT00000117285.2
    6. XM_063266134.1XP_063122204.1  muscular LMNA-interacting protein isoform X13

    7. XM_063266132.1XP_063122202.1  muscular LMNA-interacting protein isoform X6

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
    8. XM_039082517.2XP_038938445.1  muscular LMNA-interacting protein isoform X3

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:386639
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:591827
      MLIP; Muscular LMNA-interacting protein
    9. XM_039082516.2XP_038938444.1  muscular LMNA-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Related
      ENSRNOP00000097271.2, ENSRNOT00000105297.2
      Conserved Domains (2) summary
      PHA03307
      Location:438691
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:643879
      MLIP; Muscular LMNA-interacting protein
    10. XM_039082520.2XP_038938448.1  muscular LMNA-interacting protein isoform X6

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Related
      ENSRNOP00000095106.2, ENSRNOT00000113615.2
      Conserved Domains (2) summary
      PHA03307
      Location:365618
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:570806
      MLIP; Muscular LMNA-interacting protein
    11. XM_039082521.2XP_038938449.1  muscular LMNA-interacting protein isoform X5

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:413666
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:618806
      MLIP; Muscular LMNA-interacting protein
    12. XM_039082519.2XP_038938447.1  muscular LMNA-interacting protein isoform X6

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:365618
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:570806
      MLIP; Muscular LMNA-interacting protein
    13. XM_039082522.2XP_038938450.1  muscular LMNA-interacting protein isoform X8

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:361614
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:566802
      MLIP; Muscular LMNA-interacting protein
    14. XM_039082524.2XP_038938452.1  muscular LMNA-interacting protein isoform X9

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:413666
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:618782
      MLIP; Muscular LMNA-interacting protein
    15. XM_039082525.2XP_038938453.1  muscular LMNA-interacting protein isoform X10

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (3) summary
      PHA03307
      Location:413666
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK10118
      Location:325492
      PRK10118; flagellar hook length control protein FliK
      pfam15274
      Location:687760
      MLIP; Muscular LMNA-interacting protein
    16. XM_039082518.2XP_038938446.1  muscular LMNA-interacting protein isoform X4

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Conserved Domains (2) summary
      PHA03307
      Location:413666
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:618826
      MLIP; Muscular LMNA-interacting protein
    17. XM_063266133.1XP_063122203.1  muscular LMNA-interacting protein isoform X11

      UniProtKB/TrEMBL
      A0A096MJS3, A0A8I6AMD7
    18. XM_039082528.2XP_038938456.1  muscular LMNA-interacting protein isoform X14

      Conserved Domains (1) summary
      pfam15274
      Location:113295
      MLIP; Muscular LMNA-interacting protein
    19. XM_039082527.1XP_038938455.1  muscular LMNA-interacting protein isoform X12

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Related
      ENSRNOP00000076453.2, ENSRNOT00000120266.2
      Conserved Domains (2) summary
      PHA03307
      Location:361614
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:566774
      MLIP; Muscular LMNA-interacting protein
    20. XM_039082529.1XP_038938457.1  muscular LMNA-interacting protein isoform X16

      Conserved Domains (1) summary
      pfam15274
      Location:113271
      MLIP; Muscular LMNA-interacting protein
    21. XM_039082523.1XP_038938451.1  muscular LMNA-interacting protein isoform X7

      UniProtKB/Swiss-Prot
      A0A096MK47, A0A8I6ARD4, D4A3C4, Q569A0
      Related
      ENSRNOP00000099958.1, ENSRNOT00000143920.1
      Conserved Domains (2) summary
      PHA03307
      Location:413666
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15274
      Location:618802
      MLIP; Muscular LMNA-interacting protein
    External link. Please review our privacy policy.