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    Dclk1 doublecortin-like kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83825, updated on 9-Dec-2024

    Summary

    Symbol
    Dclk1provided by RGD
    Full Name
    doublecortin-like kinase 1provided by RGD
    Primary source
    RGD:68437
    See related
    EnsemblRapid:ENSRNOG00000032922 AllianceGenome:RGD:68437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ania4; Cpg16; Dcamkl1
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The typical protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the protein is independent of its protein kinase activity. This gene is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the full-length nature of the variant produced from the 5' promoter has not been determined. Current reference sequence data represents two alternatively spliced transcript variants produced from the 3' promoter and their protein products lack the doublecortin domain.[provided by RefSeq, Sep 2010]
    Expression
    Biased expression in Brain (RPKM 154.5), Spleen (RPKM 30.3) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dclk1 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141567215..141861088)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (139417234..139710956)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (144646255..144939389)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil domain containing 169 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 2 Neighboring gene uncharacterized LOC134485918 Neighboring gene uncharacterized LOC102552324 Neighboring gene uncharacterized LOC134485917 Neighboring gene uncharacterized LOC134485618 Neighboring gene uncharacterized LOC134485619 Neighboring gene neurobeachin

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables microtubule binding  
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 28
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in axon extension  
    involved_in axon extension  
    acts_upstream_of_or_within axon extension  
    involved_in axoneme assembly  
    acts_upstream_of_or_within axonogenesis  
    acts_upstream_of_or_within brain development  
    involved_in central nervous system projection neuron axonogenesis  
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis  
    involved_in chromatin remodeling  
    involved_in dendrite morphogenesis  
    acts_upstream_of_or_within dendrite morphogenesis  
    involved_in forebrain development  
    acts_upstream_of_or_within forebrain development  
    involved_in intracellular signal transduction  
    involved_in negative regulation of protein localization to nucleus  
    acts_upstream_of_or_within negative regulation of protein localization to nucleus  
    involved_in neuron migration  
    acts_upstream_of_or_within neuron migration  
    acts_upstream_of_or_within peptidyl-serine phosphorylation  
    involved_in protein localization to nucleus  
    involved_in protein localization to nucleus  
    acts_upstream_of protein localization to nucleus  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of postsynapse assembly  
    involved_in regulation of postsynapse assembly  
    involved_in response to virus  
    involved_in response to virus  
    involved_in retina development in camera-type eye  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    located_in axon PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in growth cone PubMed 
    located_in neuron projection  
    is_active_in postsynapse  
    located_in postsynaptic density  
    located_in postsynaptic density  

    General protein information

    Preferred Names
    serine/threonine-protein kinase DCLK1
    Names
    double cortin and calcium/calmodulin-dependent protein kinase-like 1
    doublecortin-like and CAM kinase-like 1
    NP_067595.1
    NP_445795.1
    XP_008759227.1
    XP_017446627.1
    XP_017446628.2
    XP_038959175.1
    XP_038959177.1
    XP_038959178.1
    XP_038959180.1
    XP_038959181.1
    XP_038959182.1
    XP_038959183.1
    XP_038959184.1
    XP_038959185.1
    XP_038959186.1
    XP_038959188.1
    XP_063138709.1
    XP_063138710.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021584.2NP_067595.1  serine/threonine-protein kinase DCLK1 isoform 2

      See identical proteins and their annotated locations for NP_067595.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is produced from the 3' promoter. It lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform [2, also known as ania-4, or CARP (CaMK-related peptide)] is only 56 aa long and mainly consists of the serine/proline-rich domain.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      Q9R1P9, Q9WVP7
    2. NM_053343.3NP_445795.1  serine/threonine-protein kinase DCLK1 isoform 1

      See identical proteins and their annotated locations for NP_445795.1

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant [1, also known as DCLK-short-A, DCK-beta2, KIAA0369-BL or cpg16 (candidate plasticity gene 16)] is produced from the 3' promoter. It encodes isoform 1, which contains a serine/proline-rich domain and a protein kinase domain.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08875
      UniProtKB/TrEMBL
      A6JVF1, A6JVF3
      Related
      ENSRNOP00000076341.3, ENSRNOT00000093407.3
      Conserved Domains (2) summary
      smart00220
      Location:83340
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14095
      Location:82339
      STKc_DCKL; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      141567215..141861088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103249.2XP_038959177.1  serine/threonine-protein kinase DCLK1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AMY9
      Conserved Domains (3) summary
      cd14183
      Location:399666
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    2. XM_039103254.2XP_038959182.1  serine/threonine-protein kinase DCLK1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AMY9
      Conserved Domains (3) summary
      cd14183
      Location:399666
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    3. XM_039103247.2XP_038959175.1  serine/threonine-protein kinase DCLK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWQ8, A0A8I6AMY9
      Related
      ENSRNOP00000083313.1, ENSRNOT00000107822.2
      Conserved Domains (3) summary
      cd14183
      Location:399666
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    4. XM_017591139.3XP_017446628.2  serine/threonine-protein kinase DCLK1 isoform X5

      UniProtKB/TrEMBL
      A0A1W2Q6Q2, A0A8I6AMY9
      Related
      ENSRNOP00000090378.2, ENSRNOT00000099182.2
      Conserved Domains (3) summary
      cd14183
      Location:383650
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    5. XM_039103250.2XP_038959178.1  serine/threonine-protein kinase DCLK1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q9WS43, A0A8I6AMY9
      Conserved Domains (3) summary
      cd14183
      Location:383650
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    6. XM_039103253.2XP_038959181.1  serine/threonine-protein kinase DCLK1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AMY9
      Conserved Domains (3) summary
      cd14183
      Location:382649
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    7. XM_039103252.2XP_038959180.1  serine/threonine-protein kinase DCLK1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AMY9
      Conserved Domains (3) summary
      cd14183
      Location:382649
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    8. XM_039103257.2XP_038959185.1  serine/threonine-protein kinase DCLK1 isoform X13

      UniProtKB/TrEMBL
      A0A0G2KB92, M0RDS3
      Conserved Domains (2) summary
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    9. XM_039103258.2XP_038959186.1  serine/threonine-protein kinase DCLK1 isoform X13

      UniProtKB/TrEMBL
      A0A0G2KB92, M0RDS3
      Conserved Domains (2) summary
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    10. XM_039103260.2XP_038959188.1  serine/threonine-protein kinase DCLK1 isoform X13

      UniProtKB/TrEMBL
      A0A0G2KB92, M0RDS3
      Related
      ENSRNOP00000075702.2, ENSRNOT00000078337.3
      Conserved Domains (2) summary
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    11. XM_063282640.1XP_063138710.1  serine/threonine-protein kinase DCLK1 isoform X14

      UniProtKB/TrEMBL
      Q9R1P9, Q9WVP7
    12. XM_063282639.1XP_063138709.1  serine/threonine-protein kinase DCLK1 isoform X9

    13. XM_017591138.3XP_017446627.1  serine/threonine-protein kinase DCLK1 isoform X8

      UniProtKB/TrEMBL
      A0A8L2QB01, A6JVF1
    14. XM_008761005.4XP_008759227.1  serine/threonine-protein kinase DCLK1 isoform X11

      Related
      ENSRNOP00000019748.8, ENSRNOT00000019748.11
      Conserved Domains (1) summary
      cd14183
      Location:76343
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    15. XM_039103256.2XP_038959184.1  serine/threonine-protein kinase DCLK1 isoform X12

    16. XM_039103255.2XP_038959183.1  serine/threonine-protein kinase DCLK1 isoform X10

      UniProtKB/TrEMBL
      A6JVF1
      Conserved Domains (1) summary
      cd14095
      Location:81338
      STKc_DCKL; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like)
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