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    Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362156, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zdhhc5provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 5provided by RGD
    Primary source
    RGD:1589737
    See related
    EnsemblRapid:ENSRNOG00000006832 AllianceGenome:RGD:1589737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DHHC-5
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in dendrite. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization, intracellular component. Orthologous to human ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 196.5), Kidney (RPKM 193.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Zdhhc5 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90178734..90206889, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69772037..69800142, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72090526..72118406, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene selenoprotein H Neighboring gene thioredoxin-related transmembrane protein 2 Neighboring gene mediator complex subunit 19 Neighboring gene uncharacterized LOC120101590 Neighboring gene cleavage factor polyribonucleotide kinase subunit 1 Neighboring gene yippee-like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity  
    enables palmitoyltransferase activity  
    enables protein-cysteine S-palmitoyltransferase activity  
    enables protein-cysteine S-palmitoyltransferase activity  
    Process Evidence Code Pubs
    involved_in innate immune response  
    involved_in lipid transport  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of pattern recognition receptor signaling pathway  
    involved_in positive regulation of pattern recognition receptor signaling pathway  
    involved_in positive regulation of protein localization to phagocytic vesicle  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of pyroptotic inflammatory response  
    involved_in positive regulation of pyroptotic inflammatory response  
    involved_in protein localization to plasma membrane  
    acts_upstream_of_or_within protein palmitoylation  
    involved_in protein palmitoylation  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    located_in dendrite PubMed 
    located_in dendrite  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in phagocytic vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  
    is_active_in postsynaptic specialization, intracellular component PubMed 
    is_active_in postsynaptic specialization, intracellular component PubMed 

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC5
    Names
    membrane-associated DHHC5 zinc finger protein
    probable palmitoyltransferase ZDHHC5
    zinc finger DHHC domain-containing protein 5
    zinc finger, DHHC domain containing 5
    zinc finger, DHHC-type containing 5
    NP_001034427.1
    XP_017447385.1
    XP_017447386.1
    XP_017447387.1
    XP_038961338.1
    XP_063140208.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039338.1NP_001034427.1  palmitoyltransferase ZDHHC5

      See identical proteins and their annotated locations for NP_001034427.1

      Status: PROVISIONAL

      Source sequence(s)
      AY871203
      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
      Related
      ENSRNOP00000009708.4, ENSRNOT00000009708.7
      Conserved Domains (1) summary
      pfam01529
      Location:99224
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      90178734..90206889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591896.3XP_017447385.1  palmitoyltransferase ZDHHC5 isoform X1

      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
      Conserved Domains (1) summary
      pfam01529
      Location:99224
      zf-DHHC; DHHC palmitoyltransferase
    2. XM_017591898.3XP_017447387.1  palmitoyltransferase ZDHHC5 isoform X1

      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
      Conserved Domains (1) summary
      pfam01529
      Location:99224
      zf-DHHC; DHHC palmitoyltransferase
    3. XM_017591897.3XP_017447386.1  palmitoyltransferase ZDHHC5 isoform X1

      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
      Conserved Domains (1) summary
      pfam01529
      Location:99224
      zf-DHHC; DHHC palmitoyltransferase
    4. XM_039105410.2XP_038961338.1  palmitoyltransferase ZDHHC5 isoform X2

      UniProtKB/TrEMBL
      A6HMR0
      Conserved Domains (1) summary
      pfam01529
      Location:46171
      DHHC; DHHC palmitoyltransferase
    5. XM_063284138.1XP_063140208.1  palmitoyltransferase ZDHHC5 isoform X1

      UniProtKB/Swiss-Prot
      Q2THW7
      UniProtKB/TrEMBL
      A6HMR0
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