U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Atad5 ATPase family, AAA domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303348, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atad5provided by RGD
    Official Full Name
    ATPase family, AAA domain containing 5provided by RGD
    Primary source
    RGD:1561464
    See related
    EnsemblRapid:ENSRNOG00000021903 AllianceGenome:RGD:1561464
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561464
    Summary
    Predicted to enable DNA binding activity and DNA clamp unloader activity. Predicted to be involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of DNA replication; and positive regulation of cell cycle G2/M phase transition. Predicted to act upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Predicted to be part of Elg1 RFC-like complex. Predicted to be active in nucleus. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 103.6), Spleen (RPKM 72.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Atad5 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65568569..65616379)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65070682..65118489)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67427042..67475825)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene ribosomal protein L12, pseudogene 6 Neighboring gene cytokine receptor-like factor 3 Neighboring gene phosphoglycerate mutase 1, pseudogene 3 Neighboring gene transcription elongation factor, mitochondrial

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables DNA binding  
    enables DNA clamp unloader activity  
    enables DNA clamp unloader activity  
    Process Evidence Code Pubs
    involved_in DNA clamp unloading  
    acts_upstream_of_or_within DNA damage response  
    involved_in biological_process  
    involved_in cell population proliferation  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  
    acts_upstream_of isotype switching  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  
    involved_in nuclear DNA replication  
    acts_upstream_of_or_within positive regulation of B cell proliferation  
    involved_in positive regulation of DNA replication  
    involved_in positive regulation of cell cycle G2/M phase transition  
    acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes  
    acts_upstream_of_or_within regulation of mitotic cell cycle phase transition  
    acts_upstream_of_or_within signal transduction in response to DNA damage  
    Component Evidence Code Pubs
    part_of Elg1 RFC-like complex  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    ATPase family AAA domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65568569..65616379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_220750.11XP_220750.6  ATPase family AAA domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_220750.6

      UniProtKB/TrEMBL
      A6HHA2, D4A058
      Related
      ENSRNOP00000028975.5, ENSRNOT00000035642.8
      Conserved Domains (1) summary
      cl21455
      Location:11211166
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_039087647.2XP_038943575.1  ATPase family AAA domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      A6HHA2
      Related
      ENSRNOP00000099936.1, ENSRNOT00000133075.1
      Conserved Domains (1) summary
      PRK04195
      Location:10451348
      PRK04195; replication factor C large subunit; Provisional
    3. XM_006246963.5XP_006247025.1  ATPase family AAA domain-containing protein 5 isoform X3

      See identical proteins and their annotated locations for XP_006247025.1

      UniProtKB/TrEMBL
      A6HHA2
      Related
      ENSRNOP00000108956.1, ENSRNOT00000136626.1
      Conserved Domains (1) summary
      cl21455
      Location:10581103
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_010055697.1 RNA Sequence

    External link. Please review our privacy policy.