Cd163 CD163 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd163provided by RGD
Official Full Name: CD163 moleculeprovided by RGD
Primary source: RGD:1310382
See related: EnsemblRapid:ENSRNOG00000010253 AllianceGenome:RGD:1310382
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ED2
Summary: Predicted to enable scaffold protein binding activity. Located in cell surface. Biomarker of traumatic brain injury and uveitis. Orthologous to human CD163 (CD163 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 505.2), Liver (RPKM 139.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4q42

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (158770751..158804146)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (157085080..157118470)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (156752063..156785467)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
Title: Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
An increased number of CD163(+) chondrocytes with enhanced phagocytic activity were discovered within degraded joint cartilage, indicating a role in eliminating degraded tissues.
Title: The identification of CD163 expressing phagocytic chondrocytes in joint cartilage and its novel scavenger role in cartilage degradation.
Significant parenchymal CD163+ cell accumulation is observed two days post traumatic brain injury and continuously increased in the investigated survival time.
Title: Lesional accumulation of CD163+ macrophages/microglia in rat traumatic brain injury.
identify CD163 on macrophages as an adhesion receptor for erythroblasts in erythroblastic islands, and suggest a regulatory role for CD163 during erythropoiesis
Title: The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor.
A broadly expressed macrophage scavenger receptor that may play a role in the activation of macrophages during hemolytic and/or inflammatory conditions.
Title: The rat macrophage scavenger receptor CD163: expression, regulation and role in inflammatory mediator production.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: scavenger receptor cysteine-rich type 1 protein M130

Names: CD163 antigen; cluster of differentiation 163

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107887.1 → NP_001101357.1 scavenger receptor cysteine-rich type 1 protein M130 precursor

See identical proteins and their annotated locations for NP_001101357.1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/TrEMBL

A6ILI0, D3Z9U2

Related

ENSRNOP00000104317.1, ENSRNOT00000152480.1

Conserved Domains (2) summary

smart00202
Location:721 → 821

SR; Scavenger receptor Cys-rich

pfam00530
Location:726 → 821

SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

158770751..158804146

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237352.5 → XP_006237414.1 scavenger receptor cysteine-rich type 1 protein M130 isoform X1

UniProtKB/TrEMBL

A0A0G2JVY2, D3Z9U2

Related

ENSRNOP00000069665.2, ENSRNOT00000084588.3

Conserved Domains (2) summary

smart00202
Location:721 → 821

SR; Scavenger receptor Cys-rich

pfam00530
Location:726 → 821

SRCR; Scavenger receptor cysteine-rich domain
XM_017592650.3 → XP_017448139.1 scavenger receptor cysteine-rich type 1 protein M130 isoform X2

UniProtKB/TrEMBL

D3Z9U2
XM_017592651.3 → XP_017448140.1 scavenger receptor cysteine-rich type 1 protein M130 isoform X2

UniProtKB/TrEMBL

D3Z9U2

Related

ENSRNOP00000058828.2, ENSRNOT00000068407.3