Zcchc8 zinc finger CCHC-type containing 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zcchc8provided by RGD
Official Full Name: zinc finger CCHC-type containing 8provided by RGD
Primary source: RGD:1309774
See related: EnsemblRapid:ENSRNOG00000001243 AllianceGenome:RGD:1309774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be located in nuclear body. Predicted to be part of TRAMP complex and catalytic step 2 spliceosome. Orthologous to human ZCCHC8 (zinc finger CCHC-type containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 98.7), Spleen (RPKM 78.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (38530037..38553595)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32869170..32892707)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38303665..38327174)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway	IEA Inferred from Electronic Annotation more info
involved_in co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TRAMP complex	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger CCHC domain-containing protein 8

Names: zinc finger, CCHC domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001400968.1 → NP_001387897.1 zinc finger CCHC domain-containing protein 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I6GJE8, A6J135, D3ZUL8

Related

ENSRNOP00000001668.6, ENSRNOT00000001668.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

38530037..38553595

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089238.2 → XP_038945166.1 zinc finger CCHC domain-containing protein 8 isoform X3

UniProtKB/TrEMBL

A0A8I5ZQ77

Conserved Domains (1) summary

cl02643
Location:208 → 260

PSP
XM_006249334.5 → XP_006249396.1 zinc finger CCHC domain-containing protein 8 isoform X2

UniProtKB/TrEMBL

A0A8I5ZR78, A0A8I6GJE8

Related

ENSRNOP00000080646.1, ENSRNOT00000098796.2

Conserved Domains (2) summary

pfam00098
Location:229 → 246

zf-CCHC; Zinc knuckle

cl02643
Location:285 → 337

PSP; PSP
XM_063271178.1 → XP_063127248.1 zinc finger CCHC domain-containing protein 8 isoform X4

UniProtKB/TrEMBL

A0A8I5ZQ77
XM_039089237.2 → XP_038945165.1 zinc finger CCHC domain-containing protein 8 isoform X1

UniProtKB/TrEMBL

A0A8I6ASZ6, A0A8I6GJE8

Related

ENSRNOP00000095166.1, ENSRNOT00000108167.2

Conserved Domains (2) summary

pfam00098
Location:204 → 221

zf-CCHC; Zinc knuckle

cl02643
Location:260 → 312

PSP
XM_039089240.2 → XP_038945168.1 zinc finger CCHC domain-containing protein 8 isoform X5

UniProtKB/TrEMBL

A6J137

Conserved Domains (2) summary

pfam00098
Location:42 → 59

zf-CCHC; Zinc knuckle

cl02643
Location:98 → 150

PSP
XM_063271179.1 → XP_063127249.1 zinc finger CCHC domain-containing protein 8 isoform X5

UniProtKB/TrEMBL

A6J137

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001105929.1: Suppressed sequence

Description

NM_001105929.1: This RefSeq was removed because currently there is insufficient support for the transcript.