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    Srf serum response factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501099, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srfprovided by RGD
    Official Full Name
    serum response factorprovided by RGD
    Primary source
    RGD:1559787
    See related
    EnsemblRapid:ENSRNOG00000018232 AllianceGenome:RGD:1559787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559787
    Summary
    Enables histone deacetylase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; long-term memory; and positive regulation of transcription by glucose. Predicted to be located in chromatin; cytoplasm; and nucleus. Used to study hepatocellular carcinoma and hypertension. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 201.3), Muscle (RPKM 157.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Srf in Genome Data Viewer
    Location:
    9q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21924050..21933338)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14426453..14435734)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16737637..16747226)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 7 Neighboring gene uncharacterized LOC120094784 Neighboring gene cullin 9 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables chromatin DNA binding  
    enables chromatin binding  
    enables histone deacetylase binding PubMed 
    enables primary miRNA binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables serum response element binding  
    enables serum response element binding  
    Items 1 - 25 of 82
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    acts_upstream_of_or_within actin filament organization  
    acts_upstream_of_or_within associative learning  
    acts_upstream_of axon extension  
    acts_upstream_of_or_within bicellular tight junction assembly  
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis  
    acts_upstream_of_or_within bronchus cartilage development  
    involved_in cardiac muscle cell myoblast differentiation  
    acts_upstream_of_or_within cardiac myofibril assembly  
    acts_upstream_of_or_within cardiac vascular smooth muscle cell differentiation  
    acts_upstream_of_or_within cell migration involved in sprouting angiogenesis  
    involved_in cell migration involved in sprouting angiogenesis  
    acts_upstream_of_or_within cell-cell adhesion  
    acts_upstream_of_or_within cell-matrix adhesion  
    involved_in cellular response to glucose stimulus PubMed 
    involved_in cellular senescence  
    acts_upstream_of_or_within contractile actin filament bundle assembly  
    acts_upstream_of_or_within developmental growth  
    acts_upstream_of_or_within dorsal aorta morphogenesis  
    acts_upstream_of_or_within epithelial cell-cell adhesion  
    acts_upstream_of_or_within epithelial structure maintenance  
    acts_upstream_of_or_within erythrocyte development  
    acts_upstream_of_or_within establishment of skin barrier  
    acts_upstream_of_or_within eyelid development in camera-type eye  
    acts_upstream_of_or_within face development  
    acts_upstream_of filopodium assembly  
    acts_upstream_of_or_within forebrain development  
    acts_upstream_of_or_within gastrulation  
    acts_upstream_of_or_within heart development  
    acts_upstream_of_or_within heart looping  
    acts_upstream_of_or_within heart trabecula formation  
    acts_upstream_of_or_within hematopoietic stem cell differentiation  
    acts_upstream_of_or_within hippocampus development  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within leukocyte differentiation  
    involved_in long-term memory PubMed 
    acts_upstream_of_or_within long-term synaptic depression  
    acts_upstream_of_or_within lung morphogenesis  
    acts_upstream_of_or_within lung smooth muscle development  
    acts_upstream_of_or_within megakaryocyte development  
    acts_upstream_of_or_within mesoderm formation  
    acts_upstream_of_or_within morphogenesis of an epithelial sheet  
    acts_upstream_of_or_within muscle cell cellular homeostasis  
    involved_in negative regulation of amyloid-beta clearance  
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of miRNA transcription  
    acts_upstream_of_or_within neuron migration  
    acts_upstream_of_or_within neuron projection development  
    acts_upstream_of_or_within platelet activation  
    acts_upstream_of_or_within platelet formation  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of axon extension  
    acts_upstream_of_or_within positive regulation of cell differentiation  
    acts_upstream_of_or_within positive regulation of filopodium assembly  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of smooth muscle contraction  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by glucose PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    acts_upstream_of_or_within positive thymic T cell selection  
    acts_upstream_of_or_within primitive streak formation  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of cell adhesion  
    involved_in response to cytokine  
    involved_in response to hormone  
    involved_in response to hypoxia  
    acts_upstream_of_or_within sarcomere organization  
    acts_upstream_of_or_within skin morphogenesis  
    acts_upstream_of_or_within stress fiber assembly  
    acts_upstream_of_or_within tangential migration from the subventricular zone to the olfactory bulb  
    acts_upstream_of_or_within thymus development  
    acts_upstream_of_or_within thyroid gland development  
    acts_upstream_of_or_within trachea cartilage development  
    acts_upstream_of transcription by RNA polymerase II  
    acts_upstream_of_or_within trophectodermal cell differentiation  
    Items 1 - 25 of 82
    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    serum response factor
    Names
    serum response factor (c-fos serum response element-binding transcription factor)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109302.2 → NP_001102772.1  serum response factor

      See identical proteins and their annotated locations for NP_001102772.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JIQ4, D3ZHH8
      Related
      ENSRNOP00000058149.3, ENSRNOT00000061430.5
      Conserved Domains (1) summary
      cd00266
      Location:138 → 219
      MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21924050..21933338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084061.2 → XP_038939989.1  serum response factor isoform X1

      Conserved Domains (2) summary
      COG5068
      Location:136 → 406
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00266
      Location:138 → 219
      MADS_SRF_like; SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in ...
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