Mlh3 mutL homolog 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mlh3provided by RGD
Official Full Name: mutL homolog 3provided by RGD
Primary source: RGD:1309227
See related: EnsemblRapid:ENSRNOG00000006699 AllianceGenome:RGD:1309227
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP hydrolysis activity; centromeric DNA binding activity; and chromatin binding activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within DNA damage response; meiotic nuclear division; and protein localization. Predicted to be located in male germ cell nucleus and nuclear lumen. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 56.4), Heart (RPKM 49.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (110612535..110649408, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (104881483..104917686, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (109059386..109095876, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127516 (e-PCR)
- UniSTS:210826

RH129328 (e-PCR)
- UniSTS:212635

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables centromeric DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within female meiosis I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mismatch repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptonemal complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chiasma	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
part_of mismatch repair complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mismatch repair complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA mismatch repair protein Mlh3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108043.1 → NP_001101513.1 DNA mismatch repair protein Mlh3

See identical proteins and their annotated locations for NP_001101513.1

Status: PROVISIONAL

Source sequence(s)

CH473982

UniProtKB/TrEMBL

A6JE18, A6JE19, D4ADG4

Related

ENSRNOP00000038334.3, ENSRNOT00000033493.5

Conserved Domains (3) summary

smart00853
Location:1179 → 1359

MutL_C; MutL C terminal dimerisation domain

cd03486
Location:206 → 349

MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...

cd16926
Location:9 → 192

HATPase_MutL-MLH-PMS-like; Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

110612535..110649408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240312.5 → XP_006240374.1 DNA mismatch repair protein Mlh3 isoform X2

UniProtKB/TrEMBL

A0A8I6APJ9, A6JE19

Related

ENSRNOP00000090967.1, ENSRNOT00000102201.2

Conserved Domains (4) summary

smart00853
Location:1147 → 1327

MutL_C; MutL C terminal dimerisation domain

cd03486
Location:206 → 349

MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...

TIGR00585
Location:1 → 326

mutl; DNA mismatch repair protein MutL

pfam02518
Location:22 → 149

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
XM_006240311.5 → XP_006240373.1 DNA mismatch repair protein Mlh3 isoform X1

UniProtKB/TrEMBL

A6JE19

Conserved Domains (4) summary

smart00853
Location:1176 → 1356

MutL_C; MutL C terminal dimerisation domain

cd03486
Location:206 → 349

MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...

TIGR00585
Location:1 → 326

mutl; DNA mismatch repair protein MutL

pfam02518
Location:22 → 149

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
XM_063261941.1 → XP_063118011.1 DNA mismatch repair protein Mlh3 isoform X4

UniProtKB/TrEMBL

A6JE19
XM_006240313.5 → XP_006240375.1 DNA mismatch repair protein Mlh3 isoform X3

UniProtKB/TrEMBL

A6JE19

Conserved Domains (3) summary

cd03486
Location:206 → 349

MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...

TIGR00585
Location:1 → 326

mutl; DNA mismatch repair protein MutL

pfam02518
Location:22 → 149

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
XM_006240314.5 → XP_006240376.1 DNA mismatch repair protein Mlh3 isoform X5

UniProtKB/TrEMBL

A6JE19

Conserved Domains (3) summary

cd03486
Location:206 → 349

MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...

TIGR00585
Location:1 → 326

mutl; DNA mismatch repair protein MutL

pfam02518
Location:22 → 149

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase