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    Cdc25c cell division cycle 25C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc25cprovided by RGD
    Official Full Name
    cell division cycle 25Cprovided by RGD
    Primary source
    RGD:1311875
    See related
    EnsemblRapid:ENSRNOG00000024008 AllianceGenome:RGD:1311875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable WW domain binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in spermatogenesis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in endometrial cancer and prostate cancer. Orthologous to human CDC25C (cell division cycle 25C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 50.8), Spleen (RPKM 37.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc25c in Genome Data Viewer
    Location:
    18p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26608483..26630292, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26335156..26356199, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27528768..27550316, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 20A Neighboring gene cell division cycle 23 Neighboring gene GDNF family receptor alpha 3 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108348765 Neighboring gene stem-loop binding protein like Neighboring gene family with sequence similarity 53, member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of cdc25 phosphatases in the germ cells of the rat testis. Mizoguchi S, et al. Biol Reprod, 1997 Jun. PMID 9166700
    2. Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability. Vassileva V, et al. Cancer Res, 2002 Jul 15. PMID 12124347
    3. Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Srivastava SK, et al. Carcinogenesis, 2003 Oct. PMID 12896904
    4. Alteration of G2 cell cycle regulators occurs during carcinogenesis of the endometrium. Tsuda H, et al. Oncology, 2003. PMID 12931023
    5. HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor. Lokeshwar VB, et al. Cancer Res, 2005 Sep 1. PMID 16140946

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of CDC25C in NPCs Disturbed Cortical Neurogenesis.
      Title: Downregulation of CDC25C in NPCs Disturbed Cortical Neurogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    M-phase inducer phosphatase 3
    NP_001388252.1
    XP_038952799.1
    XP_038952800.1
    XP_038952801.1
    XP_063133442.1
    XP_063133443.1
    XP_063133444.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401323.1 → NP_001388252.1  M-phase inducer phosphatase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      D4ADT2
      Related
      ENSRNOP00000057498.4, ENSRNOT00000037368.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      26608483..26630292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277373.1 → XP_063133443.1  M-phase inducer phosphatase 3 isoform X1

      UniProtKB/TrEMBL
      D4ADT2

    2. XM_063277372.1 → XP_063133442.1  M-phase inducer phosphatase 3 isoform X1

      UniProtKB/TrEMBL
      D4ADT2

    3. XM_063277374.1 → XP_063133444.1  M-phase inducer phosphatase 3 isoform X2

    4. XM_039096873.2 → XP_038952801.1  M-phase inducer phosphatase 3 isoform X5

      UniProtKB/TrEMBL
      A6J2V8
      Conserved Domains (1) summary
      cd01530
      Location:89 → 208
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

    5. XM_039096872.2 → XP_038952800.1  M-phase inducer phosphatase 3 isoform X4

    6. XM_039096871.2 → XP_038952799.1  M-phase inducer phosphatase 3 isoform X3

    RNA

    1. XR_005496040.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107396.1: Suppressed sequence

      Description
      NM_001107396.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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