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    Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uap1provided by RGD
    Official Full Name
    UDP-N-acetylglucosamine pyrophosphorylase 1provided by RGD
    Primary source
    RGD:1561967
    See related
    EnsemblRapid:ENSRNOG00000002926 AllianceGenome:RGD:1561967
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561967
    Summary
    Enables UDP-N-acetylglucosamine diphosphorylase activity and carbohydrate binding activity. Involved in UDP-N-acetylglucosamine metabolic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 209.5), Lung (RPKM 149.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uap1 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (84875719..84910706, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (82342946..82377558, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (88463532..88497901, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene discoidin domain receptor tyrosine kinase 2 Neighboring gene uncharacterized LOC102549303 Neighboring gene uncharacterized LOC130014439 Neighboring gene U2AF homology motif kinase 1 Neighboring gene spermine synthase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization and tissue distribution of sialic acid precursor-forming enzymes. Van Rinsum J, et al. Biochem J, 1983 Jan 15. PMID 6303311, Free PMC Article
    2. The cellular fate of glucose and its relevance in type 2 diabetes. Bouché C, et al. Endocr Rev, 2004 Oct. PMID 15466941
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine diphosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine diphosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine pyrophosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylhexosamine pyrophosphorylase
    Names
    UDP-N-acteylglucosamine pyrophosphorylase 1
    NP_001178859.1
    XP_006250284.1
    XP_006250285.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191930.2 → NP_001178859.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AUT9, D3ZF39
      Conserved Domains (1) summary
      cd04193
      Location:88 → 410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

    2. NM_001429958.1 → NP_001416887.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 2

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AUT9

    3. NM_001429959.1 → NP_001416888.1  UDP-N-acetylhexosamine pyrophosphorylase isoform 3

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AUT9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      84875719..84910706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250222.3 → XP_006250284.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X1

      Related
      ENSRNOP00000055358.4, ENSRNOT00000058560.5
      Conserved Domains (1) summary
      cd04193
      Location:88 → 410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc

    2. XM_006250223.3 → XP_006250285.1  UDP-N-acetylhexosamine pyrophosphorylase isoform X2

      Related
      ENSRNOP00000099045.1, ENSRNOT00000168466.1
      Conserved Domains (1) summary
      cd04193
      Location:88 → 410
      UDPGlcNAc_PPase; UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc
    Nucleotide Protein Strain
    Heading Accession and Version

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