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    Cep112 centrosomal protein 112 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep112provided by RGD
    Official Full Name
    centrosomal protein 112provided by RGD
    Primary source
    RGD:1564168
    See related
    EnsemblRapid:ENSRNOG00000024557 AllianceGenome:RGD:1564168
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc46; RGD1564168
    Summary
    Acts upstream of or within receptor localization to synapse. Located in inhibitory synapse and plasma membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 44. Orthologous to human CEP112 (centrosomal protein 112). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 48.1), Lung (RPKM 28.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep112 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (93865630..94332679)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (93366059..93833133)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (96660294..97146426)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene protein kinase C, alpha Neighboring gene apolipoprotein H Neighboring gene uncharacterized LOC134480891 Neighboring gene uncharacterized LOC120095198 Neighboring gene uncharacterized LOC120095199 Neighboring gene axin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Smith KR, et al. Mol Cell Neurosci, 2010 Aug. PMID 20417281, Free PMC Article
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within receptor localization to synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inhibitory synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein of 112 kDa
    Names
    centrosomal protein 112kDa
    coiled-coil domain containing 46
    coiled-coil domain-containing protein 46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105849.1 → NP_001099319.1  centrosomal protein of 112 kDa

      See identical proteins and their annotated locations for NP_001099319.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6AM07, A6HK93, D4ABV2
      Related
      ENSRNOP00000038168.8, ENSRNOT00000037067.8
      Conserved Domains (2) summary
      COG0419
      Location:430 → 997
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam14846
      Location:65 → 148
      DUF4485; Domain of unknown function (DUF4485)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      93865630..94332679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085653.2 → XP_038941581.1  centrosomal protein of 112 kDa isoform X9

      Conserved Domains (2) summary
      COG1196
      Location:346 → 688
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam14846
      Location:65 → 148
      DUF4485; Domain of unknown function (DUF4485)

    2. XM_063268762.1 → XP_063124832.1  centrosomal protein of 112 kDa isoform X6

      UniProtKB/TrEMBL
      A0A8I6AM07

    3. XM_039085650.2 → XP_038941578.1  centrosomal protein of 112 kDa isoform X4

      UniProtKB/TrEMBL
      A0A8I6AM07
      Conserved Domains (3) summary
      COG1196
      Location:569 → 911
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam02463
      Location:279 → 976
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam14846
      Location:65 → 148
      DUF4485; Domain of unknown function (DUF4485)

    4. XM_039085647.2 → XP_038941575.1  centrosomal protein of 112 kDa isoform X2

      UniProtKB/TrEMBL
      A0A8I6AM07
      Conserved Domains (2) summary
      COG0419
      Location:456 → 1023
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam14846
      Location:65 → 148
      DUF4485; Domain of unknown function (DUF4485)

    5. XM_039085646.2 → XP_038941574.1  centrosomal protein of 112 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I6AM07
      Conserved Domains (2) summary
      COG0419
      Location:456 → 1023
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam14846
      Location:65 → 148
      DUF4485; Domain of unknown function (DUF4485)

    6. XM_039085651.2 → XP_038941579.1  centrosomal protein of 112 kDa isoform X5

      UniProtKB/TrEMBL
      A0A8I6AM07
      Conserved Domains (2) summary
      COG0419
      Location:413 → 975
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam14846
      Location:65 → 148
      DUF4485; Domain of unknown function (DUF4485)

    7. XM_039085648.2 → XP_038941576.1  centrosomal protein of 112 kDa isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM07, A6HK93, D4ABV2
      Related
      ENSRNOP00000102345.1, ENSRNOT00000143597.1
      Conserved Domains (2) summary
      COG0419
      Location:430 → 997
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam14846
      Location:65 → 148
      DUF4485; Domain of unknown function (DUF4485)

    8. XM_063268763.1 → XP_063124833.1  centrosomal protein of 112 kDa isoform X8

      UniProtKB/TrEMBL
      A0A8I6AM07
      Related
      ENSRNOP00000081445.2, ENSRNOT00000094758.2

    9. XM_039085652.2 → XP_038941580.1  centrosomal protein of 112 kDa isoform X7

      UniProtKB/TrEMBL
      A0A8I6AM07
      Conserved Domains (2) summary
      COG0419
      Location:404 → 971
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam14846
      Location:13 → 96
      DUF4485; Domain of unknown function (DUF4485)

    RNA

    1. XR_005489758.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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