Sgpp2 sphingosine-1-phosphate phosphatase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sgpp2provided by RGD
Official Full Name: sphingosine-1-phosphate phosphatase 2provided by RGD
Primary source: RGD:1565739
See related: EnsemblRapid:ENSRNOG00000069992 AllianceGenome:RGD:1565739
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565739
Summary: Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; regulation of type B pancreatic cell proliferation; and sphingosine metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SGPP2 (sphingosine-1-phosphate phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 81.1), Brain (RPKM 56.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (87211155..87331787)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (79762658..79884665)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (84203094..84321269)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D9Got91 (e-PCR)
- UniSTS:113993

D9Mco89 (e-PCR)
- UniSTS:526200

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in sphingosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sphingosine-1-phosphate phosphatase 2

Names: sphingosine-1-phosphate phosphotase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191811.1 → NP_001178740.1 sphingosine-1-phosphate phosphatase 2

Status: INFERRED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AGX4

Related

ENSRNOP00000105259.1, ENSRNOT00000146930.1

Conserved Domains (2) summary

COG0671
Location:40 → 191

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03388
Location:39 → 188

PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

87211155..87331787

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083380.2 → XP_038939308.1 sphingosine-1-phosphate phosphatase 2 isoform X1

Conserved Domains (1) summary

cd03388
Location:1 → 105

PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...
XM_063266995.1 → XP_063123065.1 sphingosine-1-phosphate phosphatase 2 isoform X2
XM_039083382.2 → XP_038939310.1 sphingosine-1-phosphate phosphatase 2 isoform X2

Conserved Domains (1) summary

cd03388
Location:39 → 171

PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...
XM_039083381.2 → XP_038939309.1 sphingosine-1-phosphate phosphatase 2 isoform X1

Conserved Domains (1) summary

cd03388
Location:1 → 105

PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...