Cfb complement factor B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfbprovided by RGD
Official Full Name: complement factor Bprovided by RGD
Primary source: RGD:2204
See related: EnsemblRapid:ENSRNOG00000051235 AllianceGenome:RGD:2204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bf; Da1-24
Summary: Predicted to enable serine-type endopeptidase activity. Involved in complement activation; response to lipopolysaccharide; and response to thyroid hormone. Located in extracellular space. Biomarker of polycystic kidney disease and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (complement factor B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 6570.5), Lung (RPKM 1275.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3975271..3981138)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3970643..3976510)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (4536206..4542073, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI255840 (e-PCR)
- UniSTS:181007

RH130836 (e-PCR)
- UniSTS:214120

AI195813 (e-PCR)
- UniSTS:160646

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroid hormone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: complement factor B

Names: B-factor, properdin; properdin factor B

NP_997631.2

EC 3.4.21.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212466.3 → NP_997631.2 complement factor B precursor

See identical proteins and their annotated locations for NP_997631.2

Status: VALIDATED

Source sequence(s)

BC087089, BG380277

UniProtKB/TrEMBL

A6KTM2, G3V615, Q6MG74

Related

ENSRNOP00000000477.5, ENSRNOT00000000477.8

Conserved Domains (5) summary

cd00033
Location:102 → 157

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00020
Location:491 → 750

Tryp_SPc; Trypsin-like serine protease

smart00032
Location:54 → 82

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

cd00190
Location:486 → 754

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cd01470
Location:268 → 465

vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...