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    Ccr1l1 chemokine (C-C motif) receptor 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccr1l1provided by RGD
    Official Full Name
    chemokine (C-C motif) receptor 1-like 1provided by RGD
    Primary source
    RGD:1308007
    See related
    EnsemblRapid:ENSRNOG00000083822 AllianceGenome:RGD:1308007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable C-C chemokine receptor activity; chemokine (C-C motif) ligand 5 binding activity; and chemokine (C-C motif) ligand 7 binding activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be active in cytoplasm and external side of plasma membrane. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Ccr1l1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (132467425..132478489, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (123589997..123613767, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (133127220..133128290, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene transcription initiation factor TFIID subunit 13-like Neighboring gene C-C motif chemokine receptor 1 Neighboring gene C-C motif chemokine receptor 3 Neighboring gene Tarbp2 subunit of RISC loading complex, pseudogene 1 Neighboring gene C-C motif chemokine receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine (C-C motif) ligand 5 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine (C-C motif) ligand 7 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of monocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C-C chemokine receptor 1-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106872.1 → NP_001100342.1  C-C chemokine receptor 1-like protein 1

      See identical proteins and their annotated locations for NP_001100342.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A6I4D0, D3ZFW8
      Related
      ENSRNOP00000108021.1, ENSRNOT00000161113.1
      Conserved Domains (2) summary
      cd14964
      Location:36 → 63
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:36 → 313
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      132467425..132478489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081322.2 → XP_038937250.1  C-C chemokine receptor 1-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6I4D0, D3ZFW8
      Conserved Domains (2) summary
      cd14964
      Location:36 → 63
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:36 → 313
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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