Tifab TIFA inhibitor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tifabprovided by RGD
Official Full Name: TIFA inhibitorprovided by RGD
Primary source: RGD:1311681
See related: EnsemblRapid:ENSRNOG00000011947 AllianceGenome:RGD:1311681
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311681
Summary: Predicted to enable deubiquitinase activator activity. Predicted to be involved in several processes, including cochlea morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to act upstream of with a negative effect on toll-like receptor signaling pathway. Predicted to act upstream of or within several processes, including hemopoiesis; lipopolysaccharide-mediated signaling pathway; and regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. Orthologous to human TIFAB (TIFA inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 70.1), Thymus (RPKM 19.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (8438622..8441750)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (8433406..8436541)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9234948..9239266)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131325 (e-PCR)
- UniSTS:214608

RPLP1 (e-PCR)
- UniSTS:266204

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables deubiquitinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in auditory behavior	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in genitalia development	ISO Inferred from Sequence Orthology more info
involved_in genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hard palate morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in learned vocalization behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mastication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of relaxation of muscle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in thorax and anterior abdomen determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in trigeminal nerve development	ISO Inferred from Sequence Orthology more info
involved_in vestibulocochlear nerve formation	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TRAF-interacting protein with FHA domain-containing protein B

Names: TIFA inhibitor B; TIFA-like protein; TRAF-interacting protein with forkhead-associated domain, family member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.