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    Edar ectodysplasin-A receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Edarprovided by RGD
    Official Full Name
    ectodysplasin-A receptorprovided by RGD
    Primary source
    RGD:1561714
    See related
    EnsemblRapid:ENSRNOG00000028598 AllianceGenome:RGD:1561714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561714
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cytokine-mediated signaling pathway; positive regulation of JNK cascade; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including hair follicle development; positive regulation of non-canonical NF-kappaB signal transduction; and salivary gland cavitation. Predicted to be located in apical part of cell. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 46.1), Muscle (RPKM 12.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Edar in Genome Data Viewer
    Location:
    20q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (27130934..27209672, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26587836..26666543, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28179132..28263092, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RAN binding protein 2 Neighboring gene coiled-coil domain containing 138 Neighboring gene uncharacterized LOC103694417 Neighboring gene SH3 domain containing ring finger 3 Neighboring gene uncharacterized LOC134483911

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia. Monreal AW, et al. Nat Genet, 1999 Aug. PMID 10431241
    2. Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia. Del-Pozo J, et al. Dis Model Mech, 2019 Apr 25. PMID 31028034, Free PMC Article
    3. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Jaskoll T, et al. Anat Rec A Discov Mol Cell Evol Biol, 2003 Apr. PMID 12629675
    4. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Yan M, et al. Science, 2000 Oct 20. PMID 11039935
    5. The genetics of Sleek: a possible regulatory mutation of the tabby-crinkled-downless syndrome. Crocker M, et al. Genet Res, 1979 Dec. PMID 544312

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within salivary gland cavitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member EDAR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191899.2 → NP_001178828.1  tumor necrosis factor receptor superfamily member EDAR precursor

      See identical proteins and their annotated locations for NP_001178828.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      D3ZGP2
      Conserved Domains (2) summary
      cd13421
      Location:13 → 148
      TNFRSF_EDAR; Tumor necrosis factor receptor superfamily member ectodysplasin A receptor (EDAR)
      cl14633
      Location:354 → 428
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      27130934..27209672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098902.2 → XP_038954830.1  tumor necrosis factor receptor superfamily member EDAR isoform X2

      Conserved Domains (2) summary
      cd13421
      Location:13 → 148
      TNFRSF_EDAR; Tumor necrosis factor receptor superfamily member ectodysplasin A receptor (EDAR)
      cl14633
      Location:355 → 429
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_039098903.2 → XP_038954831.1  tumor necrosis factor receptor superfamily member EDAR isoform X3

      UniProtKB/TrEMBL
      D3ZGP2
      Related
      ENSRNOP00000029258.5, ENSRNOT00000030348.8
      Conserved Domains (2) summary
      cd13421
      Location:13 → 148
      TNFRSF_EDAR; Tumor necrosis factor receptor superfamily member ectodysplasin A receptor (EDAR)
      cl14633
      Location:355 → 429
      DD; Death Domain Superfamily of protein-protein interaction domains

    3. XM_039098901.1 → XP_038954829.1  tumor necrosis factor receptor superfamily member EDAR isoform X1

      Conserved Domains (2) summary
      cd13421
      Location:13 → 148
      TNFRSF_EDAR; Tumor necrosis factor receptor superfamily member ectodysplasin A receptor (EDAR)
      cl14633
      Location:356 → 430
      DD; Death Domain Superfamily of protein-protein interaction domains
    Nucleotide Protein Strain
    Heading Accession and Version

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