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    Usp22 ubiquitin specific peptidase 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303201, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp22provided by RGD
    Official Full Name
    ubiquitin specific peptidase 22provided by RGD
    Primary source
    RGD:1310354
    See related
    EnsemblRapid:ENSRNOG00000032492 AllianceGenome:RGD:1310354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; histone deubiquitinase activity; and nuclear receptor coactivator activity. Predicted to contribute to cysteine-type deubiquitinase activity and histone H4 acetyltransferase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of mitotic cell cycle; and regulation of gene expression. Predicted to act upstream of or within protein deubiquitination. Predicted to be part of SAGA complex. Orthologous to human USP22 (ubiquitin specific peptidase 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 493.1), Adrenal (RPKM 237.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Usp22 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46328092..46354939, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45828619..45855468, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47429201..47453298, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SRA stem-loop interacting RNA binding protein, pseudogene 1 Neighboring gene TNF receptor superfamily member 13B Neighboring gene small nucleolar RNA SNORA48 Neighboring gene aldehyde dehydrogenase 3 family, member A1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables enzyme binding  
    enables histone H2A deubiquitinase activity  
    enables histone H2B deubiquitinase activity  
    contributes_to histone H4 acetyltransferase activity  
    enables nuclear receptor coactivator activity  
    enables transcription coactivator activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    part_of SAGA complex  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 22
    Names
    ubiquitin specific protease 22
    NP_001178573.1
    XP_063125078.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191644.2NP_001178573.1  ubiquitin carboxyl-terminal hydrolase 22

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZTX7
      Related
      ENSRNOP00000044118.5, ENSRNOT00000050061.7
      Conserved Domains (2) summary
      cd02660
      Location:176518
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:63123
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46328092..46354939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269008.1XP_063125078.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

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