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    Mis18bp1 MIS18 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689296, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Mis18bp1provided by RGD
    Official Full Name
    MIS18 binding protein 1provided by RGD
    Primary source
    RGD:1594757
    See related
    EnsemblRapid:ENSRNOG00000023093 AllianceGenome:RGD:1594757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305497
    Summary
    Predicted to be part of CENP-A recruiting complex. Predicted to be active in chromosome, centromeric region. Orthologous to human MIS18BP1 (MIS18 binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 96.9), Spleen (RPKM 68.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mis18bp1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (88918743..88968225, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (83182497..83231978, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (86879106..86925209, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 39 Neighboring gene FKBP prolyl isomerase 3 Neighboring gene FA complementation group M Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion like 1 Neighboring gene voltage-dependent anion channel 1, pseudogene 15 Neighboring gene uncharacterized LOC134479286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of CENP-A recruiting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mis18-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109531.1 → NP_001103001.1  mis18-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001103001.1

      Status: VALIDATED

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HBT4, D3ZKM9
      Related
      ENSRNOP00000034593.3, ENSRNOT00000029411.6
      Conserved Domains (3) summary
      smart00717
      Location:734 → 778
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:735 → 778
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam09133
      Location:336 → 423
      SANTA; SANTA (SANT Associated)

    2. NM_001434026.1 → NP_001420955.1  mis18-binding protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      88918743..88968225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240138.5 → XP_006240200.1  mis18-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZZ6
      Conserved Domains (3) summary
      smart00717
      Location:801 → 845
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:802 → 845
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam09133
      Location:336 → 423
      SANTA; SANTA (SANT Associated)

    2. XM_063262505.1 → XP_063118575.1  mis18-binding protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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