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    Entrep1 endosomal transmembrane epsin interactor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Entrep1provided by RGD
    Official Full Name
    endosomal transmembrane epsin interactor 1provided by RGD
    Primary source
    RGD:1307524
    See related
    EnsemblRapid:ENSRNOG00000061147 AllianceGenome:RGD:1307524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam189a2; RGD1307524
    Summary
    Predicted to enable ubiquitin ligase activator activity. Predicted to be involved in CXCL12-activated CXCR4 signaling pathway and negative adaptation of signaling pathway. Predicted to be located in endosome membrane and plasma membrane. Orthologous to human ENTREP1 (endosomal transmembrane epsin interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 208.4), Heart (RPKM 89.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Entrep1 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (231018987..231073474, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (221592500..221646603, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (241822152..241876089, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 65 Neighboring gene amyloid beta precursor protein binding family A member 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120100004 Neighboring gene tight junction protein 2 Neighboring gene uncharacterized LOC134483979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin ligase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CXCL12-activated CXCR4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative adaptation of signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endosomal transmembrane epsin interactor 1
    Names
    family with sequence similarity 189, member A2
    protein FAM189A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400818.1 → NP_001387747.1  endosomal transmembrane epsin interactor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K3C3, B2GV30
      Related
      ENSRNOP00000072580.2, ENSRNOT00000091282.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      231018987..231073474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101391.2 → XP_038957319.1  endosomal transmembrane epsin interactor 1 isoform X1

      Conserved Domains (1) summary
      pfam04103
      Location:99 → 251
      CD20; CD20-like family

    RNA

    1. XR_005499600.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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