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    Ppip5k2 diphosphoinositol pentakisphosphate kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppip5k2provided by RGD
    Official Full Name
    diphosphoinositol pentakisphosphate kinase 2provided by RGD
    Primary source
    RGD:1590765
    See related
    EnsemblRapid:ENSRNOG00000011613 AllianceGenome:RGD:1590765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 5-diphosphoinositol pentakisphosphate 1-kinase activity; ATP binding activity; and inositol hexakisphosphate kinase activity. Predicted to be involved in phosphorylation. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 100. Orthologous to human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 324.6), Liver (RPKM 233.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppip5k2 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (105727906..105838159)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (98315220..98394537)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (111232967..111249613)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled 1 pseudogene 6 Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene transfer RNA proline (anticodon AGG) 31 Neighboring gene macrophage immunometabolism regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Wang H, et al. Nat Chem Biol, 2011 Nov 27. PMID 22119861, Free PMC Article
    2. Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. Fridy PC, et al. J Biol Chem, 2007 Oct 19. PMID 17690096
    3. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114398

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
    NP_001406895.1
    XP_038940805.1
    XP_038940806.1
    XP_038940813.1
    XP_038940814.1
    XP_038940817.1
    XP_038940822.1
    XP_063123704.1
    XP_063123705.1
    XP_063123706.1
    XP_063123707.1
    XP_063123708.1
    XP_063123709.1
    XP_063123710.1
    XP_063123711.1
    XP_063123712.1
    XP_063123713.1
    XP_063123714.1
    XP_063123715.1
    XP_063123716.1
    XP_063123717.1
    XP_063123718.1
    XP_063123719.1
    XP_063123720.1
    XP_063123721.1
    XP_063123722.1
    XP_063123723.1
    XP_063123724.1
    XP_063123725.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419966.1 → NP_001406895.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JR83
      Related
      ENSRNOP00000068346.3, ENSRNOT00000076729.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      105727906..105838159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267649.1 → XP_063123719.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X17

      UniProtKB/TrEMBL
      A0A096MKF1

    2. XM_063267640.1 → XP_063123710.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X11

      UniProtKB/TrEMBL
      A6JR83

    3. XM_063267645.1 → XP_063123715.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X14

      UniProtKB/TrEMBL
      A6JR83

    4. XM_063267652.1 → XP_063123722.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X18

      UniProtKB/TrEMBL
      A0A096MKF1

    5. XM_063267644.1 → XP_063123714.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X13

      UniProtKB/TrEMBL
      A6JR83

    6. XM_063267634.1 → XP_063123704.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5XWD7

    7. XM_063267639.1 → XP_063123709.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X10

      UniProtKB/TrEMBL
      A0A096MK18

    8. XM_063267638.1 → XP_063123708.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X9

      UniProtKB/TrEMBL
      A6JR82, F1LPI7
      Related
      ENSRNOP00000068491.3, ENSRNOT00000076669.4

    9. XM_063267646.1 → XP_063123716.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X15

      UniProtKB/TrEMBL
      A0A096MKF1

    10. XM_063267648.1 → XP_063123718.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X17

      UniProtKB/TrEMBL
      A0A096MKF1

    11. XM_063267651.1 → XP_063123721.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X18

      UniProtKB/TrEMBL
      A0A096MKF1

    12. XM_039084877.2 → XP_038940805.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5XWD7
      Related
      ENSRNOP00000107453.1, ENSRNOT00000171928.1
      Conserved Domains (3) summary
      pfam00328
      Location:379 → 894
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:44 → 133
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:48 → 337
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    13. XM_039084886.2 → XP_038940814.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X7

      UniProtKB/TrEMBL
      A0A096MK18
      Conserved Domains (3) summary
      pfam00328
      Location:379 → 894
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:44 → 133
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:48 → 337
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    14. XM_039084885.2 → XP_038940813.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4

      UniProtKB/TrEMBL
      A6JR82, F1LPI7
      Related
      ENSRNOP00000077673.2, ENSRNOT00000095195.2
      Conserved Domains (3) summary
      pfam00328
      Location:379 → 894
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:44 → 133
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:48 → 337
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    15. XM_039084889.2 → XP_038940817.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X8

      UniProtKB/TrEMBL
      A6JR82, F1LPI7
      Related
      ENSRNOP00000111260.1, ENSRNOT00000163301.1
      Conserved Domains (3) summary
      pfam00328
      Location:379 → 894
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:44 → 133
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:48 → 337
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    16. XM_063267643.1 → XP_063123713.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X14

      UniProtKB/TrEMBL
      A6JR83

    17. XM_039084878.2 → XP_038940806.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5XWD7
      Conserved Domains (3) summary
      pfam00328
      Location:379 → 893
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:44 → 133
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:48 → 337
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    18. XM_063267636.1 → XP_063123706.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X5

      UniProtKB/TrEMBL
      A6JR82, F1LPI7

    19. XM_063267637.1 → XP_063123707.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X6

      UniProtKB/TrEMBL
      A6JR82, F1LPI7

    20. XM_039084894.2 → XP_038940822.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X13

      UniProtKB/TrEMBL
      A6JR83
      Conserved Domains (3) summary
      pfam00328
      Location:379 → 893
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:44 → 133
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:48 → 337
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    21. XM_063267647.1 → XP_063123717.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X16

      UniProtKB/TrEMBL
      A6JR83

    22. XM_063267650.1 → XP_063123720.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X17

      UniProtKB/TrEMBL
      A0A096MKF1

    23. XM_063267641.1 → XP_063123711.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12

      UniProtKB/TrEMBL
      A6JR83

    24. XM_063267642.1 → XP_063123712.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12

      UniProtKB/TrEMBL
      A6JR83
      Related
      ENSRNOP00000099420.1, ENSRNOT00000130944.1

    25. XM_063267635.1 → XP_063123705.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4

      UniProtKB/TrEMBL
      A6JR82, F1LPI7

    26. XM_063267653.1 → XP_063123723.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X19

      UniProtKB/TrEMBL
      A6JR83

    27. XM_063267654.1 → XP_063123724.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5XWD7

    28. XM_063267655.1 → XP_063123725.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X21

      UniProtKB/TrEMBL
      A6JR82, F1LPI7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025775.1: Suppressed sequence

      Description
      NM_001025775.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PPIP5K2 (GeneID:23262).
    Nucleotide Protein Strain
    Heading Accession and Version

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